Human bone marrow granulocyte-macrophageal colonies (GM-Cs) in vitro: myeloid cells in health and in cases of myeloid leukemia.

The morphological characteristics of granulocyte/macrophageal (GM-) colonies and clusters, obtained in vitro (in semi-solid agar cultures) from bone marrow hematopoietic myeloid progenitors pertain to leukocyte hemorheology of healthy persons and patients with myeloid leukemias. The morphological features of in vitro growing myeloid progenitors, granulocytes and macrophages of healthy persons differ in their cell size, shape and degree of differentiation from the cultivated marrow cells in cases of acute and chronic myeloid leukaemia. In this malignant disease, the rheological properties of leukocytes (granulocytes/macrophages) were found to provide diagnostic information.

[Choice of the anti-arrhythmia drug and antitachycardia pacemakers in persistent tachycardias].

In 57 patients with recurrent tachycardiac attacks in whom the empiric medical drug treatment failed to prevent the attacks electrophysiological examination was carried out in order to specify the type of the tachycardia. This was followed up by a serial testing of drugs. In 41 patients an antiarrhythmic drug (or a combination of drugs) was found which could prevent the attacks.

[Reproduction of tachycardias in patients with WPW syndrome].

Intracavitary electrophysiological study of the heart (IES) was carried out in 27 patients with WPW syndrome. In 17/27, permanent tachycardia, reentry type was reproduced, in 1/27--unstable and in 2/27--echo phenomenon, in 1/27--atrial fibrillation. In 6/27 no tachycardia was reproduced.

[Effect of 1 month's treatment with Bezalip on the serum lipids and lipoproteins of patients with different types of hyperlipoproteinemias].

The effect of one-month bezalip (600 mg daily) outpatient department treatment was studied on serum lipids and lipoproteins of 34 patients (31 males and 3 females), aged from 30 to 60 with various types primary HLP (IIA, IIB, IV and V). After the treatment, it was established that tendency to malization of the increased concentrations of triglycerides (Tg) and cholesterol (Chol) was changed. The drug has a stronger effect on triglyceride component of serum VIDLP and LDLP as compared with the corresponding cholesterol one, due to which its treatment is with better effect in IIB, IV and V type HLP.

[Electrophysiologic characteristics of the syndrome of ventricular preexcitation].

In nine patients with syndrome of ventricular over-excitation of intracavitary electrocardiographic investigation was carried out, including recording of Hiss bundle potentials, right and left auricle, programmed, increment and high frequent stimulations. The anatomic characteristic of the additional connection, on the base of the deformation of QRS-complex and the type of the retrograde conduction in case of ventricular stimulation showed that the connection started from the right auricle. In five--it terminates in the left ventricle, and in four--in the right.

[Determination of the effect of furanthril on myocardial infarct lesion size according to precordial electrocardiogram (mapping) and enzyme activity findings].

The ECG Mapping from 30 precordial points in 56 patients with recent anterior transmural infarctions was followed up as well as the level of the enzymes, acid phosphokinase, SGOT and LDH-iso during the first 6 days after the origination of the cardiac infarction. Thirty six patients were treated according to the generally adopted treatment schedule of cardiac infarction (group without furanthril) and 20 patients were administered, in addition to the generally adopted schedule, one tablet furanthril daily during the first six days (group with furanthril. Though no manifested discrepancies were observed in the indices studied in both groups (without and with furanthril)--in patients administered furanthril systematically--a better manifested drop was found in ECG Mapping indices and the enzyme activity in the course of the cardiac infarction, as compared with the group without furanthril.

[Changes in serum lipoproteins in patients with ischemic heart disease at an early age].

The serum lipoprotein profile was determined in 37 patients with chronic ischemic heart disease (IHD) and 100 practically healthy subjects, aged from 18 to 45. HLP was found in 59.5 per cent of the patients examined, 50 per cent in males and 100 per cent in females.

[Assessment of sinus node function using electrophysiological methods].

Intracardial electrophysiological examination was conducted in 50 patients with suspicious or confirmed data about disturbed function of sinus node--namely: short-term auricular stimulation for determination of sinoatrial time (SAT) and long-term auricular stimulation with increasing frequency with analysis of the phenomena in the post-stimulation period--time of sinus node recovery (TSNR), corrected recovery time of sinus node (CRTSN=TSNR minus the basal cycle of auricle before stimulation), emerging of ectopic rhythm leaders and secondary pauses. The following data were obtained in the two groups of patients formed: Group I--26 patients with ECG data about disturbed function of sinus node (periods of sinus bradycardia under 40 beats (minute and/or sinus pauses over 1800 msec): SAT identical to 375 +/- 168; TSNR = 2714 +/- 562; CRTSN = 1684 +/- 347; SAT over 400 msec was found in 8 out of 22 patients; TSNR over 1400 msec in 20 out of 26 patients, CRTSN over 550 msec in 20 out of 26 patients. Ectopic rhythm leader occurred in the poststimulation interval in 5 out of 26 patients and in 4 patients--secondary pauses over 1800 msec were observed; Group II--24 patients, with no data about disturbed function of sinus node (according to the upper criteria): SAT = 254 +/- 91; TSNR +/- 1082 +/- 168; CRTSN = 326 +/- 108; SAT over 400 msec was observed in none of the patients from that group.

[Recording of the potential of the bundle of His in patients with disordered atrioventricular conduction].

The potentials of His bundle were recorded in 25, out of 105 patients with intracardial electrophysiological examination, carried out. The standard electrocardiographic devices were used, being reconstructed for the purpose. The patients with AV block, stage I and partial AV block, Wenckebach type manifested blocking (slow down) above His bundle.

[Clinical characteristics, immediate therapeutic results and the outcome in rhythm and conductivity disturbances in myocardial infarct].

Certain rhythm and conduction disorders in 252 patients with myocardial infarction were studied. Twenty one of them had auricular fibrillation, influenced by medicaments, with the exception of one, six had relapses and 4 of the patients died. Ventricular extrasystoles (frequent, polytopic, more than three one after the other, R of T) were found in 48 patients.

[Comparative study of the therapeutic effect of antiangina agents].

The therapeutic effect of obsidan (25 to 250 mg/24 h), cordanum (75 to 300 mg/24 h), nitropenton (30 mg/24 h), combination of obsidan with nitropenton, prenylamin (180 mg/24 h), stenopril (180 mg/24 h), cordaron (600 mg/24h) and corvaton (4 mg/24 h) was studied according to clinical asessment in 127 patients with stenocardia and in 44 of them by loading tests (veloergometry or treadmill). According to the clinical assessment -- very good (abating of stenocardia paroxysms) and good effect (less frequent paroxysms nitroglycerin necessary every one-two days) was established in 82 per cent of those treated with obsidan, in 78 per cent of the treated with cordanum, in 86 per cent of those treated with the combination obsidan with nitropenton, in 44 per cent of the treated with nitropenton, in 42 per cent of the treated with prenylamin, in 46 per cent pf the treated with stenopril, in 7 out of 9 patients treated with cordaron as well as in 7 out of 9 patients treated with corvaton. According to the data from the loading tests--very good (increase of capacity, not limited by pain and ST depression) and good effect (considerable increase of capacity but limited by pain and ST depression) was found in 77 per cent of the patients administered obsidan, in 67 per cent of those administered cardanum and in 33 per cent of the patients administered tenopril and prenylamin.

[Clinical use of electrical atrial stimulation].

Electric auricle stimulation (EAS) was realized in a total of 77 patients. In 60 of the patients EAS was performed as a hypoxic test (step-wise increase of heart rate, with ECG registration and in many of the cases -- registration of certain indices of general and intracardial hemodynamics) with a view to precise diagnosis of ischemic heart disease and assessment of myocardial contraction function. In 91 per cent of the patients with stenosed coronary pathology on coronarogram, the symptoms of coronary insufficiency were positive (pain attack, ECG changes via ischemic type and/or deterioration of the myocardial functional curve) with the aid of EAS.

[Precordial electrocartography (mapping) in cardiac infarct].

After a detailed literature survey the authors share the results from the precordial electromapping with the registration of 30 points upon the chest in 34 patients with ischemic heart disease (30 with transmural infarction and 4 with intermediary syndrome). The following indices were followed up: sigmaST (the sum of the elevation of ST segment measured at 60 msec of the S deflection recording) and the index nST (the sum of the points with an elevation greater than 0.1 mV/1 mm).

[Comparison of precordial electrocartography with pathologicoanatomic data on 20 patients with recent myocardial infarct].

In 20 patients with recent myocardial infarction, that died till the 40th day after the onset of the disease, a comparison is made of the data from the pathologoanatomical findings with the indices from the precordial electromapping. The changes in the ST segment of the precordial electromapping correlate, to a significant extent, to the weight of the infarction zone in patients with interior site of the myocardial infarction (sigmaST r = 0.89, p less than or equal to 0.