[Influence of treatment with olmesartan on ambulatory blood pressure monitoring parameters in patients with arterial hypertension].

Hypertension is the most common disease of the cardiovascular system. Active treatment of hypertension with adequate control of blood pressure (BP) can prevent complications, improve life quality and increase life expectancy. One of the interesting new antihypertensive agents, from the group of angiotensin receptor blockers is olmesartan.

[Genetic aspects of atrial fibrillation in coronary artery disease patients].

To examine the relationship I/D polymorphism of the angiotensin-converting enzyme (ACE) gene and polymorphism A1166S of angiotensin II type 1 receptor (AT2R1) gene with the development of atrial fibrillation (AF) in patients with coronary artery disease (CAD), the residents of Kharkiv region. The study involved 318 patients with CAD, of whom 54 (17,0%) patients with CHD and AF were included in group I, 264 (93,0%) patients without AF - in group II. The control group included 35 people without atherosclerotic and morphological changes of spacecraft.

[Comparison of the therapeutic effect of the Warfarin and Rivaroksaban among the patients with not-valuate fibrillation of atrium].

In this article the results of comparative assessment of the efficiency of the Rivaroksaban and Varfarine for prevention of stroke and systemic embolic complications in middle and high- stroke risk patients with nonvalvular artial fibrillation are presented. Detailed analysis of some risk factors is conducted according to scales: CHADS2, CHA2DS2-VASc and HAS-BLED. The frequency of development of endpoints is defined (stroke, TIA, system embolism, cardiac infarction or death due to cardiovascular reasons, or combination of outcomes) according to initial risk and anticoagulant treatment.

[Polymorphism of the angiotensin-converting enzyme gene in cardiovascular pathology].

The aim of the study was to investigate influence of polymorphism of angiotensin-converting enzyme (ACE) gene on peculiarities of clinical process of such cardiovascular pathology as hypertrophic cardiomyopathy, coronary arterial disease and arterial hypertension. The polymorphism of ACE gene was studied in 98 patients: 38 with hypertrophic cardiomyopathy, 35 with coronary arterial disease and 25 with arterial hypertension. Nuclear DNA was extracted from blood leukocytes by phenol-chloroform method.

[Central hemodynamic status in young patients with myocardial ischemia].

Results are submitted of investigations designed to study central hemodynamics and intracardiac kinetics in young patients with ischemic heart disease (IHD). In young coronary patients the course of the disease has been shown to be more often accompanied by the development of cardiac aneurism than in the elder ones in spite of the presence in the latter of more significant changes in their echocardiograms. Concomitant with aggravation of clinical manifestations of IHD (higher functional class of stable angina) there is an increase in the size of the left ventricle and decrease in the ejection fraction.

[The apoB genotype and the efficacy of hypolipidemic therapy].

Several men were examined for association between restriction fragment length polymorphism (RELP) Xba I (exon 26) number of tandem repeats in 3'-hypervariable region of the apolipoprotein-B gene and serum levels of cholesterol and triglyceride. These two types of polymorphism were studied. An association of the Xba I site and alleles containing more repeats in the 3'-hypervariable region with higher cholesterol and triglyceride was observed.

[Thrombocytic hemostasis and the system of vasoactive prostanoids in IHD patients with hypoalphacholesterolemia].

With a purpose to study the state of platelet haemostasis and vasoactive prostanoids system 78 patients with ischemic heart disease aged 28 to 59 years were examined. Among them there were 22 patients with "isolated" hypo-alpha-cholesterolemia and 14 patients who had hypo-alpha-cholesterolemia combined with hypertriglyceridemia (HTG). The data obtained show that hypo-alpha-cholesterolemia is accompanied by platelet disorders aggravation and characterized by activated platelet percentage growth.

[The relationship of the restriction fragment length polymorphism of the apo-B gene to the blood lipid spectrum in patients with ischemic heart disease].

Restriction fragment length polymorphism of the apo-B gene at the Xbal restriction site was detected. The association between RFLP of the apo-B gene and the level of lipid metabolism indices was revealed. The levels of total cholesterol LDLP CH and atherogenicity coefficient were significantly higher in homozygotes with this restriction site (X2X2) than in homozygotes X1X1 and heterozygotes.

[The lipid metabolic indices of patients with different outcomes in unstable angina].

An association has been established between lipid metabolism, clinical course and immediate prognosis of unstable angina. It has been shown that the low level of the main protein of high density lipoproteins Apo-I in unstable stenocardia is prognostically unfavourable criterion for the development of acute myocardial infarction.

[The mechanisms of the hereditary predisposition to ischemic heart disease].

The hereditary predisposition of people to ischemic cardiac disease may be realized both by means of the lipid blood spectrum and through the break-down thrombosis processes. The argument mentioned is confirmed by the strong fixed correlation between patients who had infarction-myocarditis at young age and their children.

[Clinico-genealogical characteristics of patients with ischemic heart disease and different disorders of lipid metabolism].

The paper presents a clinical and genealogical characterization of 50 probands suffering from coronary heart disease concurrent with various lipid metabolic disturbances and 211 first-degree relatives whose data have been obtained from the probands' histories while making up their pedigrees. The prevalence of atherosclerosis among the first-degree relatives has been demonstrated to be related to the nature of lipid metabolic disturbances in a proband. Some dyslipoproteinemias in the proband have been characterized by early onset of coronary heart disease, stroke, and their grave course in close relatives.

[24-hour ECG monitoring in young patients with ischemic heart disease].

The paper presents the results of the study into the diagnostic potentialities of 24-hour ECG monitoring in young patients. The monitoring is a sensitive and informative technique for the diagnosis of coronary heart disease in young patients, allowing the signs of coronary insufficiency to be revealed in 91.4% of the patients with verified coronary heart disease.

[Regulation of apolipoprotein expression].

Recent data and concepts on the structure and functioning of apolipoprotein genes as well as on the role of hereditary factors in pathogenesis of atherosclerosis are reviewed. The most important variants of inherited disorders in the system of apolipoproteins promoting the development of atherosclerosis are considered. Special attention is paid to the RFLP of apolipoprotein genes which serves as a peculiar genetic background, increasing probability of the atherosclerosis development in certain individuals.

[The prostacyclin-thromboxane system and the functional properties of the thrombocytes in patients of different ages with ischemic heart disease].

A study is presented of the reactions of prostacyclin-thromboxane system and functions of thrombocytes to physical loads inducing myocardial ischemia in patients with ischemic heart disease of different age groups. Examined were 62 patients with stable stenocardia of the II and III functional classes. Age of the patients: from 44 to 60 years.

[The effect of a controlled physical load on the level of cyclic adenosine monophosphate in plasma and thrombocytes].

The authors studied the functional activity of thrombocytes, levels of plasma and thrombocytic cyclic AMP (cAMP) in the dynamics of a veloergometric test in patients with IHD and neurocirculatory dystonia. The revealed signs of hyperactivation of thrombocytes and absence of compensatory response of cAMP in IHD patients against the background of thresholds loads allows to improve the quality of prediction of thrombotic complications and control of treatment efficacy with agents possessing antithrombocytic activity.

[Prostaglandins and thromboxane in coronary arteriosclerosis].

The prostanoid status was assessed in 138 patients with coronary atherosclerosis and clinical signs of stable angina. Plasma prostaglandin F2 alpha and E1, and stable prostacyclin and thromboxane metabolites were measured radioimmunologically, using standard kits. A relationship is demonstrated between the severity of clinical manifestations, and pattern and magnitude of change in individual prostanoids.