[Focal myofibrillar disorganization in acute metabolic impairment of somatic musculature].

Skeletal muscles of rats and rabbits were studied by the target electron microscoptic and polarization-optic methods after administration of toxic substances and experimental acute ischemia of the extremities. Two types of foci of the myofibrillae disaggregation were described along with contracture injuries. The first occurred on the basis of relaxation and was expressed in total dysaggregation and lysis of myofibrillae; with the second type lysis occurred in the partially contracted fibers and began in the I-discs leading to diastasis of A-discs.