Comparative study of heat transfer and thermal damage assessment models for hyperthermia treatment.

Appropriate heating of the tumor can ablate tumor cells with minimal damage to healthy tissue and low side effects to the patient. Therefore, it is important to estimate power dissipation requirement and predict thermal damage in tumor before hyperthermia treatment. This work applied a mathematical model on heat transfer in two-layered spherical tissue to predict the temperature profile within hyperthermia domain.

Transplantation of human Wharton's Jelly-derived stem cells alleviates chemically induced liver fibrosis in rats.

There is currently no effective treatment method available for liver fibrosis. We therefore evaluated the use of Wharton's jelly stem cells (WJSCs; the major umbilical cord stem cell population) to treat chemically induced liver fibrosis via intraperitoneal injection of thioacetamide. WJSCs were transplanted into liver-damaged rats via the portal vein and the treatment was evaluated by assessing serum biochemistry and histopathology.

Hypoglycaemic effects of fermented mycelium of Paecilomyces farinosus (G30801) on high-fat fed rats with streptozotocin-induced diabetes.

Background & Objectives: Paceilomyces farinosus is an entomogenous fungus with a powerful insecticidal activity against the larvae of Lipidoptera, Coleoptera and Hymenoptera. However, the hypoglycaemic activity of P. farinosus extract has not been studied.

Mesenchymal stem cells facilitate recovery from chemically induced liver damage and decrease liver fibrosis.

Aims: To investigate the feasibility and mechanism of liver damage repair using human bone marrow mesenchymal stem cells (hBMMSCs), we investigated the potential for hBMMSCs in recovery from liver damage, including fibrotic liver repair, using the CCl(4)-induced model for liver damage in the rat.

Main Methods: Rats were injected with 0.5 ml/kg CCl(4) to induce liver damage and progressive liver fibrosis.

Fluvastatin attenuates severe hemorrhagic shock-induced organ damage in rats.

Objectives: Multiple organ dysfunction resulting from hemorrhagic shock (HS) and subsequent resuscitation was mediated by several inflammatory factors such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10). The present study was designed to investigate the protective effects of fluvastatin on these mediators after HS in rats.

Methods: The experimental rats were randomly divided into three groups.

Single dose intravenous thioacetamide administration as a model of acute liver damage in rats.

Thioacetamide (TAA) has been used extensively in the development of animal models of acute liver injury. Frequently, TAA is administered intraperitoneally to induce liver damage under anaesthesia. However, it is rarely administered by intravenous injection in conscious rats.