[The main trends in a complex program of rehabilitation of children with oncological diseases].

The present-day therapeutical programmes allow physicians to cure as many as 70% of children with malignant neoplasms, in some tumor forms, the proportion of recovered children is much higher, which shows it urgent to elaborate comprehensive rehabilitation programmes required for the effective integration of prior patients of children's cancer clinics into a group. The paper presents a complex rehabilitation programme worked out at the Research Institute of Pediatric Oncology and Hematology, Russian Cancer Research Center, Russian Academy of Medical Sciences. The basic directions of the programme are medical, psychological, pedagogical, and social rehabilitation.

[The rate of antipyrine metabolism in cancer patients administered specific therapy].

Liver monooxygenase (MO) activity was evaluated in 31 children with oncological diseases. The enzyme activity was assessed by measuring the saliva half life of the test drug antipyrine. It was shown that MO activity is reduced in hepatitis, metastatic lesions of the liver, after long-term chemotherapy, combined treatment or progress of disease.

[Prospects of the use of modifiers in children's oncologic radiology].

Problems of radiotherapy of malignant tumors in children are discussed. The treatment included the use of different radiation modifiers with the aid of which radiosensitivity of normal and tumorous tissues may be selectively altered, thereby reducing radiation load of normal tissues and organs adjacent to the tumor. The data are given on the treatment of 45 children with soft tissue sarcomas.

[Rhabdomyosarcoma in children].

Issues in diagnosis and complex treatment of pediatric rhabdomyosarcoma were studied in 198 patients with morphologically verified disease. Tumors most often developed in the genitourinary organs (36.6%), head and neck (37%) and--less frequently--on the trunk and extremities (26.

[Surgical stress in pediatric oncology].

Hormonal-metabolic examination was performed in 150 children suffering nephroblastoma and retroperitoneal tumors to outline features of surgical stress in pediatric cancer patients. Surgical trauma causes hyperglycemia associated with relatively low level of insulin and elevated concentration of somatotropin in blood. A reverse correlation was established between pre- and intraoperative values of many hormonal-metabolic parameters.