Development of a Monoclonal scFv against Cytotoxin to Neutralize Cytolytic Activity Induced by Venom on Myoblast C2C12 Cells.

The Taiwanese cobra, , is a clinically significant species of snake observed in the wild in Taiwan. Victims bitten by usually experience severe pain and local tissue necrosis. Although antivenom is available for treatment of cobra envenomation, its neutralization potency against cobra-induced necrosis is weak, with more than 60% of cobra envenoming patients developing tissue necrosis after antivenom administration.