[The uncoupling of the functioning of the force generation and ATP hydrolysis centers in the myocardial myofibrils in experimental informational disease].

Active and rigor force generation under the effect of electrostatic charge, the temperature and pCa, was significantly decreased in informational experimental disease. Other significant changes on the molecular level occurred in cardiomyocyte contractile apparatus in conditions of experimental informational disease.

Arterial hypertension in dogs with experimental informational pathology of their higher nervous activity.

It is shown that stable arterial hypertension can be formed in dogs by the development of experimental pathology of higher nervous activity (behavior) as a result of prolonged brain work during exposure to a combination of three unfavorable factors: a large volume of information to be processed and assimilated, shortage of time allowed for the work, and a high level of motivation of behavior. Three types of development of arterial hypertension were found, correlating with changes in behavior; self-regulating behavior reflecting defensive activity of the brain is particularly interesting. A high degree of self-regulating behavior was found to increase the resistance of the animal to arterial hypertension but weakening of self-regulation of behavior facilitates its onset and development.

[Arterial hypertension in dogs in a state of experimental informational pathology of higher nervous activity].

A stable arterial hypertension was obtained in dogs by means of experimental pathology of higher nervous activity (behavior) produced with a prolonged work of the brain in conditions of unfavourably combined triad of factors: large volume of information to be processed and assimilated, the factor of time set for such brain work, and a high level of behavioral motivation. Three types of arterial hypertension were revealed to correlate with the changes in behaviour. One form of this behaviour is the self-regulatory activity reflecting the defense mechanisms of the brain.

[Energy support and the contractile capacity of glycerinized myocardial fibers in experimental informational neurosis].

Experiments in dogs revealed that in informational neurosis the ability of myocardial contractile protein system (myocardial glycerinized filament bundles) to develop tension and produce work as well as the power of the contractile process are considerably reduced. Obviously, the energy production is not disturbed as a lower myocardial content of ATP (by 12%) and particularly of CP (by 54%) is caused by 8-9-month hypokinesia. Analogous shifts seem to occur in the human heart in informational neurosis which, in combination with the reduced intensity of the calcium transport by sarcoplasmic reticulum and mitochondria, may underlie the development of heart weakness.

[Protective and therapeutic role of internal inhibition in dogs with experimental neuroses].

In one group of unrestrained dogs positive conditioned reflexes to three feeding troughs were elaborated to sound stimuli. In the other group both positive and negative reflexes were elaborated; then a maximum in duration of the delayed response to conditioned stimuli was determined for all animals who afterwards were neurotized with three factors: big volume of information for processing and assimilation; prolonged time deficit for such brain activity, and high level of motivation. It was found that in dogs of the second group profound disorders of the higher nervous activity occurred considerably later than in the first group, and that in neurotized dogs elaboration of internal inhibition had a curative effect.

[Experimental informational neuroses in dogs as sequelae of overloading short-term memory].

In conditions of overloaded function of short-term memory, studied by the method of delayed reactions, with a prolonged deficit of time allotted for realization of the function, the animals exhibit substantial disturbances of higher nervous activity which by their etiological character belong to the group of informational neuroses. Appearance of the neurosis is preceded by a number of complex behavioral and vegetative changes reflecting activation of powerful compensatory mechanisms of the brain activity, aimed at elimating the time deficit and other neurotizing factors of the surroundings. Experimental neurosis caused by overloading the function of short-term memory is characterized by a severe course and is attended with motor and somatic disturbances as well as by memory and emotional disorders.