Ultrastructure of hippocampal field CA1 in rats after status epilepticus induced by systemic administration of kainic acid.

The ultrastructure of hippocampal field CA1 in rats was studied 14 days after status epilepticus induced by administration of kainic acid. Structural changes were seen in 40% of cells, predominantly interneurons, which showed both reversible changes (mitochondria with an electron-dense matrix or small numbers of short cristae, moderate dilation of rough endoplasmic reticulum (RER) cisterns, and small numbers of ribosomes) and more significant abnormalities: swollen mitochondria with very small numbers of cristae, which were partially degraded, some with damaged mitochondrial membranes, along with pathologically damaged RER components and focal or peripheral chromatolysis. Chromatolyzed areas sometimes contained membrane-like includes and vacuoles.

Effects of the selective lesions of cholinergic septohippocampal neurons on different forms of memory and learning process.

The aim of this study was to investigate the modulation of the hippocampal function by the cholinergic cells of the septum and the role of the septo-hippocampal cholinergic system in learning and memory. Immunotoxin 192 IgG-saporin was used to produce selective lesions of cholinergic septohippocampal neurons. Hippocampal AChE was used as a quantitative measure of lesion extent.

[Quantitative analysis of gliocytes and macrogliocyte-neuronal ratio in the rat hippocampus after kindling].

Gliosis is one of the main morphological correlates of epilepsy. It is presented predominantly by proliferation and hypertrophy of astrocytes and activated microglia (macrophages) and is most characteristic to those areas of the epileptogenic zones, where the loss of neurons is significant. One of such structures is the hippocampus, the sclerosis of which develops already at the early stages of epileptogenesis.

[The influence of myo-inositol on the ultrastructure of hippocampal CA1 area in kainate treated rats].

The ultrastructure of neurons, synapses and astrocytes of hippocampal CA1 area in rats was investigated 14 days after: systemic injection of kainic acid and kainic acid and myo-Inositol. After injection of kainic acid numerous neurons with superficial and deep ultrastructural changes of cytoplasmic organelles were described. Among synapses numerous forms with osmiophilic active zone and single synaptic vesicles, also presynaptic terminals with core vesicles were often seen.

Effect of acoustic stimulation on cell composition of auditory brain structures in Krushinskii-Molodkina rats.

We studied the effect of acoustic stimulation on cell composition of auditory brain structures in Krushinskii-Molodkina rats. Significant structural changes in the inferior colliculi of rats with high seizure activity were revealed 1 month after acoustic stimulation. Therefore, this brain structure plays a role in the development of audiogenic epileptic activity.

[Formation of spatial short-term memory in 18-54-month old children].

The development of the spatial short-term memory (SSTM) in children aged 18-54-months was assessed by performance of the inverted delayed-response task (IDR). A child perceived the localization of a target object in one of the two containers (left or right) situated on a table in front of the child. The distance between the containers was 30 cm.

[The pathogenetic and prognostic value of autonomic-hormonal shifts in ischemic stroke].

The paper deals with a study into the status of the autonomic nervous system and hormonal homeostasis in 58 patients with ischemic brain stroke. The blood content of cortisol, thyroxine, triiodothyronine and prolactin was measured by radioimmunoassay. The data obtained point to the differences in the degree of vegetative and hormonal imbalance depending on hemispheric lateralization of a pathological focus and the level of brain injury.

[Diagnosis and treatment of the Tolosa-Hunt syndrome].

An analysis of clinical data concerning 13 patients with nonpurulent inflammation of the external wall of the cavernous sinus (or the Tolosa-Hunt syndrome) permitted the authors to come to the conclusion that as a result of administration of steroid preparations the assessment of some diagnostical criteria is somewhat altered. At the same time of certain diagnostical value is the rapid therapeutical effect of steroid preparations as well as the criteria proposed by the authors-- the connection between the onset of the disease and some infectious disease (most frequently catarrh of the upper airway) and a combined lesions of the oculomotor nerves and sympathic periarterial fibres of the internal carotid artery without marked exophthalmus.