[Inhibition of prednisolone osteopathy by diphosphonate (EHDP) in an animal experiment].

The application of a low dose of prednisolone (0.4 mg per kg body weigh and day) in young hamsters leads to a loss of bone mass. This effect is inhibited by the administration of the diphosphonate EHDP (6.

[Experimental modification of the pH value of the synovial fluid of rabbits. Gas analysis studies].

After the intraarticular injection of isoosmolalic acid (pH 5.0) or alkaline (pH 10.0) buffer solutions into the right knee joints and physiological buffer solution (pH 7.

[Ultrastructural changes in articular cartilage affected by a non-physiological pH value of the synovial fluid].

The physiological pH-value of the synovial fluid (pH 7.2-7.4) is important for the integrity of normal articular cartilage.

The influence of the pH value of the synovial fluid on the articular cartilage in rabbits. A scanning electron microscopic study.

After the intraarticular injection of isoosmolaric buffer solutions with pH values of 4.0 and 10.0 or 7.

On the action of prednisolone and ethane-1-hydroxy-1,1-diphosphonate (EHDP) on rabbit bone.

Ethane-1-hydroxy-1,1-diphosphonate (EHDP) (0.1 mg and 1 mg P/kg) and prednisolone (3.7 mg/kg) were administered separately and in combination to young rabbits for a period of 100 days.

[The significance of the function of the skeletal and locomotor systems in old age (author's transl)].

Well-functioning skeletal and locomotor systems are very important for the achievement of an active old age. Modern surgical methods allow the treatment of disorders of the locomotor system in such a successful way that the frightening prospect of the patient's confinement to bed with all its considerable risks can be avoided. This holds especially for the treatment of fractured bones, degenerative arthropathies and pathological fractures.

[On the influence of D-penicillamine on collage metabolism - investigations of the rupture of strength in tailfibre in rats of several ages (author's transl)].

The tensile strength of rat tail tendons of animals wtih a different age is more influenced by D-Penicillamine (DPA) in younger rats than in elderly rats. DPA has the best effect in the regions with the highest collagen turnover. After the use of DPA the collagen of tails of the elderly rats resembles the collagen of the younger animals.

[On the treatment of the osteodystrophia deformans (Paget's disease) with synthetic salmon calcitonin (author's transl)].

Sixteen patients with Paget's disease of bone aged from 51 to 80 years was treated daily with 20 micrograms (equivalent to 80 MRCU) synthetic salmon calcitonin. Fourteen patients was observed on a long time. In all cases was observed significant reductions in increased serum alkaline phosphatase.

[Long-term therapy with calcitonin in Paget's diseases (author's transl)].

16 patients with a Paget's disease at the age of 51--80 years were treated by synthetic salmon calcitonine in a dosis of 20 mcg (80 MRCU/die). 14 patients could be observed for a longer time. In all cases there was a statically significant decrease of the increased alkaline serum phosphatase.