[Complications of surgical treatment in patients with laryngeal and hypopharyngeal cancer].

Introduction: Surgical treatment of patients with laryngeal or/and hypopharyngeal cancer is combined with potential risk of complications either local and general. The aim of the study was to evaluate the occurrence of them in the large cohort of patients with mentioned localization of cancer.

Material And Methods: The group of 447 patients, treated between 2000-2005 in Department of Otolaryngology and Laryngological Oncology, Medical University of Lublin were analyzed retrospectively.

[Epithelial cell proliferation in nasal polyps].

The mechanism stimulating the growth of nasal polyps remains unclear. The fact that nasal polyps formation is connected with increase of the epithelial surface suggests that the dysregulation of epithelial cell proliferation takes part in their pathogenesis. Furthermore, macroscopically nonsuspected nasal polyp, usually benign tissue lesion, occasionally may be misdiagnosed such as neoplasm.

[Is syndecan-1 an independent prognostic factor in patients with laryngeal carcinoma?].

Syndecan-1 is a member of the syndecan family of cell membrane heparan sulphate proteoglicans. The aim of this study was the evaluation of prognostic value of syndecan-1 expression in laryngeal cancer. The findings were correlated with the clinico-pathological parameters of the tumours, as well as with patient survival rate.

Suppressive effects of co-stimulatory molecule expressions on mouse splenocytes by anti-allergic agents in vitro.

The influence of anti-allergic drugs, epinastine hydrochloride (EP) and disodium cromoglycate (DSCG), on the co-stimulatory molecule expression was examined using in vitro cell culture technique. Spleen cells obtained from BALB/c mice 10 days after immunization with haemocyanin absorbed to aluminium hydroxide were cultured in the presence of 100.0 microg/ml haemocyanin and various concentrations of the agents.

Suppressive effects of azelastine hydrochloride on CD40 expression in mice.

The present study was designed to examine the influence of an anti-allergic agent, azelastine hydrochloride (AZ) on a co-stimulatory molecule, CD40 expression in actively sensitized mice. BALB/c mice were sensitized by intraperitoneal injection of two doses of dinitrophenylated-ovalbumin and Al(OH)3 at one-week intervals. The mice were treated orally with 0.

Influence of anti-allergic agents on in vivo expression of co-stimulatory molecules in normal mice.

The co-stimulatory signal provided by the interaction between CD28 and its ligands, CD80 and CD86, is critical for T cell activation. Engagement of CD40 and CD40L is also essential for IgE synthesis and secretion. In the present study, we examined the influence of anti-allergic drugs on co-stimulatory molecule (CD40, CD80 and CD86) expression in normal mouse splenocytes by flow cytometry.

[The results of surgical treatment of patients with laryngeal carcinoma in years 1988-1989 in four departments of otorhinolaryngology].

In a group of 579 patients with laryngeal carcinoma treated surgically in years 1988-1989 in four departments of otorhinolaryngology of the Medical Academies in Poznań, Warsaw, Cracow and Lublin, 72% survived 3 years without recurrence and 59% survived 5 years. Similar results were obtained in years 1986-1987. The authors discuss in detail the reasons for failures of the surgical treatment, i.

[Efficiency of surgical treatment in patients with laryngeal cancer depending on age].

In the group of 578 patients with larynx cancer that underwent surgical treatment in four clinics of Medical Academies between 1986-87 a comparable analysis of the efficiency of surgical treatment depending on age of the operated patients was carried out. It was found that the difference between age average and the general state of patients was statistically highly important: Statistically significant was also the dependence between the patients' age and the postoperative complications; close to importance was also the dependence between the age and the survival period of patients. 68% of operated patients up to 65 year of age had five-year survival period without any symptoms; but in the group of patients over 65 years of age the analogical survival value was 51%.

[Cytologic and histopathologic examinations of polyps and mucosa in chronic allergic and nonallergic rhinitis].

We evaluated cytograms and tissue sections of nasal polyps and mucosa of 30 patients with chronic allergic and nonallergic rhinitis. We compared them with cytograms and biopsies of 20 asymptomatic persons. We noticed a presence of neutrophils in cytograms and in biopsies of patients with allergic rhinitis and with nonallergic eosinophilic rhinitis.

[Failure of surgical treatment in patients with laryngeal neoplasm treated at the Department of Otolaryngology Medical Academy in Lublin].

We have analysed the causes of failure of surgical treatment of the patients with laryngeal carcinoma. Among 269 patients operated in different stages of the disease, 100 (37.0%) of them showed in retrospective analysis negative result of the treatment, that is the recurrence and/or death.

[Results of surgical treatment in laryngeal cancer patients based on material of the Lublin Clinic of Otolaryngology].

A group of 287 laryngeal carcinoma patients was discussed, who were operationally treated over the period of ten years (1974-1983). Three- and five-year-long symptomless survivals were presented taking into account: age, sex, environment, habits, development of cancer on the base of precancerous conditions, primary localisation, progression of cancer in the larynx, presence of nodular metastases and a degree of clinical progression. In a group of 206 patients treated only operationally there were 65% of 5-year-long symptomless survivals, in a group 61 patients treated by the combined method--33%, and finally in a group of patients with recurrence after irradiation treated operationally there were only 25% of 5-year-long survivals.