Publications by authors named "Truyen Derek Pham"
Pendrin, encoded by Slc26a4, is a Cl(-)/HCO(3)(-) exchanger expressed in the apical region of type B and non-A, non-B intercalated cells, which regulates renal NaCl excretion. Dietary Cl(-) restriction upregulates total pendrin protein expression. Whether the subcellular expression of pendrin and whether the apparent vascular volume contraction observed in Slc26a4 null mice are Cl(-) dependent, but Na(+) independent, is unknown.
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- NKCC1 null mice exhibit hypotension primarily due to a lack of NKCC1-mediated vasoconstriction, raising questions about their kidney function in sodium and water balance.
- The study investigates whether these mice have issues regulating NaCl and water that contribute to their low blood pressure and examines potential hormonal and transporter expression changes in the kidneys.
- Results show NKCC1 null mice have lower blood pressure, altered hormonal levels (like higher renin and lower ANP), and reduced ability to excrete free water, leading to issues like hypochloremia, despite increased expression of some sodium transporters.