Inflammatory disease progression shapes nanoparticle biomolecular corona-mediated immune activation profiles.

Polymeric nanoparticles (NPs) are promising tools used for immunomodulation and drug delivery in various disease contexts. The interaction between NP surfaces and plasma-resident biomolecules results in the formation of a biomolecular corona, which varies patient-to-patient and as a function of disease state. This study investigates how the progression of acute systemic inflammatory disease influences NP corona compositions and the corresponding effects on innate immune cell interactions, phenotypes, and cytokine responses.

Virtual Impressions: An Examination of OBGYN Programs' Online Presence in the Match Process: OBGYN Residency Program Websites and Social Media.

Background: The COVID pandemic led to the transition of residency applications to a virtual format and the expansion of residency programs' virtual presence.

Objective: The objective is to understand what information Obstetrics and Gynecology Residency interviewees prioritize and how influential program websites and social media platforms are.

Study Design: Electronic surveys were sent to fourth-year medical students and OBGYN residents and were available for 6 weeks in spring 2023.

Factors associated with retention in Quitline counseling for smoking cessation among HIV-positive smokers receiving care at HIV outpatient clinics in Vietnam.

Background: Quitline counseling is an effective method for supporting smoking cessation, offering personalized and accessible assistance. Tobacco use is a significant public health issue among people living with HIV. In Vietnam, over 50% of men living with HIV use tobacco.

Acid-Enhanced Photoiniferter Polymerization under Visible Light.

Photoiniferter (PI) is a promising polymerization methodology, often used to overcome restrictions posed by thermal reversible addition-fragmentation chain-transfer (RAFT) polymerization. However, in the overwhelming majority of reports, high energy UV irradiation is required to effectively trigger photolysis of RAFT agents and facilitate the polymerization, significantly limiting its potential, scope, and applicability. Although visible light PI has emerged as a highly attractive alternative, most current approaches are limited to the synthesis of lower molecular weight polymers (i.

Awake prone positioning effectiveness in moderate to severe COVID-19 a randomized controlled trial.

Background: Awake prone positioning (APP) may be beneficial in patients with respiratory failure who are not receiving mechanical ventilation. Randomized controlled trials of APP have been performed during peak COVID-19 periods in unvaccinated populations, with limited data on compliance or patient acceptability. We aimed to evaluate the efficacy and acceptability of APP in a lower-middle income country in an open-label randomized controlled trial using a dedicated APP implementation team and wearable continuous-monitoring devices.

Comparing statistical and deep learning approaches for simultaneous prediction of stand-level above- and belowground biomass in tropical forests.

Accurate and cost-effective prediction of aboveground biomass (AGB), belowground biomass (BGB), and the total (ABGB) at stand-level within tropical forests is crucial for effective forest ecological management and the provision of forest ecosystem services. Although there has been research on simultaneously fitting biomass equations for tree components, rather few studies focus on simultaneously predicting AGB and BGB at stand-level while maintaining additivity. We developed innovative Deep Learning Additive Models (DLAMs) for the simultaneous predictions of stand-level AGB, BGB, and ABGB integrating forest stand, ecological, and environmental factors as predictive covariates and compared them with conventional weighted nonlinear seemingly unrelated regression (WNSUR) and multivariate adaptive regression splines (MARS).

Breaching the Barrier: Investigating Initial Herpes Simplex Viral Infection and Spread in Human Skin and Mucosa.

Herpes simplex virus (HSV) is sexually transmitted via the anogenital mucosa where it initially infects epidermal keratinocytes and mononuclear phagocytes (MNPs). It then spreads to the dorsal root ganglion via sensory nerve endings, to remain latent for life with periodic reactivation. Currently, there is no cure or vaccine.

Neuromorphic neuromodulation: Towards the next generation of closed-loop neurostimulation.

Neuromodulation techniques have emerged as promising approaches for treating a wide range of neurological disorders, precisely delivering electrical stimulation to modulate abnormal neuronal activity. While leveraging the unique capabilities of AI holds immense potential for responsive neurostimulation, it appears as an extremely challenging proposition where real-time (low-latency) processing, low-power consumption, and heat constraints are limiting factors. The use of sophisticated AI-driven models for personalized neurostimulation depends on the back-telemetry of data to external systems (e.

Complication Rates After Ultrasonography-Guided Nerve Blocks Performed in the Emergency Department.

Importance: Ultrasonography-guided nerve blocks (UGNBs) have become a core component of multimodal analgesia for acute pain management in the emergency department (ED). Despite their growing use, national adoption of UGNBs has been slow due to a lack of procedural safety in the ED.

Objective: To assess the complication rates and patient pain scores of UGNBs performed in the ED.

Draft genome sequence of strain DS30.6, isolated from forest soil in Vietnam.

strain DS30.6 was chosen to be resistant to T2C-Rasto after being isolated from Vietnamese forest soil. The draft genome of this strain was reported to be 8,863,720 bp, with an average guanine-cytosine content of 72.

Development and Implementation of a Multicenter Registry for Resuscitation-Focused Transesophageal Echocardiography.

Study Objective: To evaluate the clinical effect, safety, and clinical outcomes of focused transesophageal echocardiography (TEE) in the evaluation of critically ill patients in the emergency department (ED) and ICUs.

Methods: We established a prospective, multicenter, observational registry involving adult critically ill patients in whom focused TEE was performed for evaluation of out-of-hospital cardiac arrest (OHCA), inhospital cardiac arrest, evaluation of undifferentiated shock, hemodynamic monitoring, and/or procedural guidance in the ED, ICU, or operating room setting. The primary objective of the current investigation was to evaluate the clinical influence and safety of focused, point-of-care TEE in critically ill patients.

Diabetes self-care intervention strategies and their effectiveness in Sub-Saharan Africa: A systematic review.

Background: Diabetes poses a significant public health challenge, predominantly affecting low-and middle-income countries (LMICs), including in Sub-Saharan Africa (SSA). The evolving landscape characterized by resource constraints, gaps in availability and functionality of healthcare system, and socio-demographic impediments has compounded these challenges. As an example, self-care interventions have played a crucial role in diabetes care.

Intervention lymphatic leakage after esophageal surgery due to esophageal cancer: A case report.

Chylothorax after esophageal surgery is a rare complication but can lead to death in patients due to malnutrition, fluid imbalance, and immunodeficiency. Multiple treatment options exist for postoperative chylothorax, including conservative treatment, octreotide therapy, and interventions such as thoracic duct embolization and surgical ligation of the thoracic duct. We present a case of lymphatic leakage following laparoscopic esophagectomy for esophageal cancer, confirmed by lymphangiography.

Replacing poly(ethylene glycol) with RAFT lipopolymers in mRNA lipid nanoparticle systems for effective gene delivery.

Lipid nanoparticles (LNPs) have emerged as promising carriers to efficiently transport mRNA into cells for protein translation, as seen with the mRNA vaccines used against COVID-19. However, they contain a widely used polymer - poly(ethylene glycol) (PEG) - which lacks the functionality to be easily modified (which could effectively control the physicochemical properties of the LNPs such as its charge), and is also known to be immunogenic. Thus, it is desirable to explore alternative polymers which can replace the PEG component in mRNA LNP vaccines and therapeutics, while still maintaining their efficacy.

New biomarkers for liver involvement by dengue infection in adult Vietnamese patients: a case-control study.

Liver injury with marked elevation of aspartate aminotransferase enzyme (AST) is commonly observed in dengue infection. To understand the pathogenesis of this liver damage, we compared the plasma levels of hepatic specific, centrilobular predominant enzymes (glutamate dehydrogenase, GLDH; glutathione S transferase-α, αGST), periportal enriched 4-hydroxyphenylpyruvate dioxygenase (HPPD), periportal predominant arginase-1 (ARG-1), and other non-specific biomarkers (paraoxonase-1, PON-1) in patients with different outcomes of dengue infection. This hospital-based study enrolled 87 adult dengue patients, stratified into three groups based on plasma AST levels (< 80, 80-400, > 400 U/L) in a 1:1:1 ratio (n = 40, n = 40, n = 40, respectively.

A mixture of grass-legume cover crop species may ameliorate water stress in a changing climate.

Climate change models predict increasing precipitation variability in the mid-latitude regions of Earth, generating a need to reduce the negative impacts of these changes on crop production. Despite considerable research on how cover crops support agriculture in a changing climate, understanding is limited of how climate change influences the growth of cover crops. We investigated the early development of two common cover crop species-crimson clover () and rye ()-and hypothesized that growing them in the mixture would ameliorate stress from drought or waterlogging.

The Influence of Vasopressors on Free Flap Outcomes in Head and Neck Cancer Patients.

Objective: To compare free flap outcomes between those who received and did not receive vasopressors (VPs) at the time of free flap reconstruction.

Study Design: This retrospective cohort study includes patients from January 2013 to January 2023.

Setting: This multicenter cohort study utilized data from the TriNetX Research Network which includes 80 health care organizations.

Immunogenicity of Abdala COVID-19 vaccine in Vietnamese people after primary and booster vaccinations: A prospective observational study in Vietnam.

Objectives: We studied the immunogenicity after primary and booster vaccinations of the Abdala COVID-19 vaccine, a receptor-binding domain protein subunit vaccine, in Vietnamese people by determining the level of neutralization and cross-neutralization activities against the ancestral SARS-CoV-2 and its variants and SARS-CoV-1.

Methods: We performed a prospective observational study, enrolling adults aged 19-59 years in Dong Thap province, southern Vietnam, and collected blood samples from baseline until 4 weeks after the booster dose. We measured anti-nucleocapsid, anti-spike, and neutralizing antibodies against SARS-CoV-2 and assessed the cross-neutralization against 14 SARS-CoV-2 variants and SARS-CoV-1.

Generalization challenges in electrocardiogram deep learning: insights from dataset characteristics and attention mechanism.

Deep learning's widespread use prompts heightened scrutiny, particularly in the biomedical fields, with a specific focus on model generalizability. This study delves into the influence of training data characteristics on the generalization performance of models, specifically in cardiac abnormality detection. Leveraging diverse electrocardiogram datasets, models are trained on subsets with varying characteristics and subsequently compared for performance.

GAN-Based Motion Artifact Correction of 3D MR Volumes Using an Image-to-Image Translation Algorithm.

The quality of brain MRI volumes is often compromised by motion artifacts arising from intricate respiratory patterns and involuntary head movements, manifesting as blurring and ghosting that markedly degrade imaging quality. In this study, we introduce an innovative approach employing a 3D deep learning framework to restore brain MR volumes afflicted by motion artifacts. The framework integrates a densely connected 3D U-net architecture augmented by generative adversarial network (GAN)-informed training with a novel volumetric reconstruction loss function tailored to 3D GAN to enhance the quality of the volumes.

Are Orthopaedic Clinical Trials Linguistically and Culturally Diverse? A Systematic Review.

Purpose: Underrepresentation and misrepresentation of historically underrepresented populations in randomized controlled trials (RCTs) may have implications for the validity of research results and their application for diverse populations. To evaluate the representation of historically linguistically, racially, and ethnically underrepresented participants in orthopaedic randomized controlled trials (RCTs) and to assess the use of translated and culturally adapted patient reported outcome measures (PROMs).

Methods: Separate and comprehensive literature searches of PubMed, Web of Science, and Embase databases were performed to identify RCTs utilizing PROMs between the years 2012 - 2022 among the top five highest 5-year impact factor orthopaedic journals according to the 2021 Journal Citation Reports database.