In vitro Biological Evaluation and In silico Studies of a New Anthraquinone from Zingiber cassumunar Roxb. in Type 2 Diabetes Management.

A novel diphenyl-anthraquinone compound, cassuquinone A, was isolated from the rhizomes of Zingiber cassumunar. Structural elucidation was accomplished using detailed NMR and HRMS-ESI  techniques, revealing a symmetrical anthraquinone core with methoxylated aromatic rings. Cassuquinone A exhibited potent α-glucosidase inhibitory activity with an IC₅₀ of 11.

Anti-inflammatory effects of LCB 03-0110 on human corneal epithelial and murine T helper 17 cells.

Dry eye disease (DED) is a complicated disorder that impacts ocular surface and tear-film stability. Inflammation has recently been reported as the core mechanism and main therapeutic target of DED. Although anti-inflammatory drugs have been developed, they still have limited efficacy and various side effects.

Additively manufactured, long, serpentine submillimeter channels by combining binder jet printing and liquid-phase sintering.

Metallic microfluidic devices made from powder-bed additive manufacturing systems have received increasing attention, but their feasible channel geometry and complexity are often limited by lack of an effective approach to removing trapped powder particles within the channels or conduits of the sintered parts. Here, we present an innovative approach to fabricating long serpentine, high-aspect-ratio submillimeter channels made of stainless steel 316L (SS) by binder jet printing (BJP) and liquid-phase sintering. We leverage the unique nature of the BJP process, that is printing and consolidation steps are decoupled, enabling us to join two or more parts during the sintering step.

The main duct of von Ebner's glands is a source of Sox10 taste bud progenitors and susceptible to pathogen infections.

We have recently demonstrated that -expressing ( ) cells give rise to mainly type-III neuronal taste bud cells that are responsible for sour and salt taste. The two tissue compartments containing cells in the surrounding of taste buds include the connective tissue core of taste papillae and von Ebner's glands (vEGs) that are connected to the trench of circumvallate and foliate papillae. In this study, we used inducible Cre mouse models to map the cell lineages of connective tissue (including stromal and Schwann cells) and vEGs and performed single cell RNA-sequencing of the epithelium of mouse circumvallate/vEG complex.

biological evaluation and studies of linear diarylheptanoids from Salisb. as urease inhibitors.

Plants of the family, specifically those belonging to the species, are commonly under consideration as potential therapeutic agents for the management of gastrointestinal diseases. In this study, we carried out a phytochemical study on Salisb. (or so-called "Nghe trang" in Vietnamese) grown in Vietnam, which yields three newly discovered 3,5-diacetoxy diarylheptanoids (1-3) and six known 3,5-dihydroxyl diarylheptanoids (4-9).

Four new species of (Sonerileae, Melastomataceae) from Vietnam.

is a genus currently treated in the polyphyletic . Recent phylogenomic analyses have identified a morphologically cohesive lineage referred to as the (raphides) clade, which should be excluded from and treated as a distinct genus under the name . Morphological and phylogenomic data have confirmed that four new species collected from Vietnam are part of the (raphides) clade.

Historical development of karst evergreen broadleaved forests in East Asia has shaped the evolution of a hemiparasitic genus (Orobanchaceae).

is a shrubby genus of about eight species distributed basically in East Asian evergreen broadleaved forests (EBLFs), with distribution centers in the karst regions of Yunnan, Guizhou, and Guangxi in southwestern China. Based on the hemiparasitic and more or less liana habits of this genus, we hypothesized that its evolution and distribution were shaped by the development of EBLFs there. To test our hypothesis, the most comprehensive phylogenies of hitherto were constructed based on plastome and nuclear loci (nrDNA, PHYA and PHYB); then divergence time and ancestral areas were inferred using the combined nuclear loci dataset.

Exceptionally well-preserved crocodilian coprolites from the Late Eocene of Northern Vietnam: Ichnology and paleoecological significance.

This study examines 55 coprolites from the Na Duong Basin to reconstruct the paleoenvironment. Coproecology sheds light on understanding the complex prey-predator relationships, trophic dynamics, and ecosystem evolution. Through quantitative and multidisciplinary analysis, the putative coprolites were attributed to crocodilian producers, leading to the establishment of a new ichnogenus and species, igen.

High-flow nasal cannula therapy in patients with COVID-19 in intensive care units in a country with limited resources: a single-center experience.

Objective: This study was performed to determine the outcomes of patients with coronavirus disease 2019 (COVID-19) who developed hypoxemic respiratory failure necessitating high-flow nasal cannula (HFNC) therapy and to identify the predictors of HFNC therapy success.

Methods: This retrospective observational study involved all patients treated with HFNC therapy at a center for COVID-19 in Viet Nam from August to October 2021.

Results: The study recruited 302 patients.

A novel diphenylbutenoid-type compound from the rhizomes of (J.Koenig) Link ex A.Dietr. (Zingiberaceae).

From the EtOAc-soluble extract of the rhizomes of (J.Koenig) Link ex A.Dietr.

A new -carboline-type alkaloid from the flowers of (L.) W.T.Aiton.

In our antioxidant screening of some Vietnamese plant extracts, the CHCl-soluble fraction from (L.) W.T.

Comparable safety profile between neuro-oncology procedures involving stereotactic needle biopsy (SNB) followed by laser interstitial thermal therapy (LITT) and LITT alone procedures.

Introduction: Tissue diagnosis through stereotactic needle biopsy (SNB) is often needed prior to laser interstitial thermal therapy (LITT). Whether these procedures should be performed in the same surgery or in separate settings remain unclear. As a first step to address this question, we assess safety profile of procedures involving LITT alone versus SNB + LITT.

Integrated pest management of Hypsipyla robusta shoot-tip borer (Lepidoptera: Pyralidae) in Chukrasia tabularis (Sapindales: Meliaceae).

Chukrasia tabularis A. Juss produces a valuable timber but plantations are susceptible to attack by the shoot-tip borer Hypsipyla robusta Moore. An integrated pest management (IPM) approach is desirable to limit the extent of damage.

Classification of Vascular Plants in Vietnam According to Modern Classification Systems.

Vietnam is extremely rich in biodiversity, with a remarkable range of habitats and more than 13,500 species of vascular plants recorded for the flora of Vietnam. This number represents about 3 to 5% of the world's diversity of vascular plants. Over the past 30 years, there were two important documents on the vascular plants of Vietnam published, (IFV) and (CPSV).

Three new species of (Sonerileae, Melastomataceae) from the Sino-Vietnamese border area.

, , and (Sonerileae, Melastomataceae), three species occurring in Sino-Vietnamese limestone karst regions, are described as new. Molecular phylogenetic analyses and morphological divergence indicate that these species are well separated from their close relatives in , justifying their recognition as distinct species. is unique in its interveinal areas prominently bullate each with an apical seta, a character otherwise never recorded in the genus.

 (Gesneriaceae), a new species from north-western Vietnam.

(Gesneriaceae), a new species from the limestone area in Son La Province, north-western Vietnam, is described here. The new species resembles , but it differs by the combination of corolla tube shape, stamens number and the length of pistil. Detailed morphological description, together with photographic plates, information on phenology, distribution, ecology and preliminary conservation status of the new species are presented.

Taxotrophises A and B, two new polyphenols from the stems of .

From the EtOAc extract of the wood of the stems of (Moraceae), two new secondary metabolites, named taxotrophises A () and B (), were isolated, together with five known compounds (-). Their chemical structures have been elucidated by extensive NMR spectroscopic analysis. All isolated compounds have been evaluated for -glucosidase inhibitory activity.

Strebluses E-H, four new stilbene-like derivatives from the stems of .

Following bioactivity-guided isolation, four new stilbene-like derivatives, named Strebluses E-H, were isolated from the EtOAc-soluble fraction of the stems of (Moraceae). Their chemical structures were elucidated based on NMR spectroscopic data interpretation and optical rotation calculation. E possesses potent tyrosinase inhibitory activity with an IC value of 0.

A New abeo-Icetexane-Type Diterpenoid from the Stem Barks of Taxus wallichiana.

From a CH Cl -soluble fraction of the stem barks of Taxus wallichiana, one new abeo-icetexane-type diterpenoid, taxamairin I (1), was isolated. Its absolute configuration was elucidated based on spectroscopic interpretation and time-dependent density functional theory (TD-DFT) calculation of optical rotation. In addition, the plausible biosynthesis pathway for the formation of the new abeo-icetexane-type diterpenoid was proposed.

Paratrimerin Z, an undescribed chromene derivative from the roots of .

From an EtOAc-soluble fraction of the roots of , one undescribed chromene derivative, paratrimerin Z (), was isolated. Its structure was elucidated on the basis of NMR spectroscopic interpretation. The absolute configuration of was determined by the specific rotation analysis of its acid-catalyzed hydrolysis product.

Leaf fossils of (Arecaceae) from the Oligocene of northern Vietnam and their paleoclimatic implications.

Recent paleobotanical investigations in Vietnam provide a good opportunity to improve our understanding of the biodiversity and paleoclimatic conditions in the geological past of Southeast Asia. Palms (Arecaceae) are a diverse family of typical thermophilous plants with a relatively low tolerance for freezing. In this study, we describe well-preserved fossil palm leaves from the Oligocene Dong Ho Formation of Hoanh Bo Basin, northern Vietnam.

Out of chaos: Phylogenomics of Asian Sonerileae.

Sonerileae is a diverse Melastomataceae lineage comprising ca. 1000 species in 44 genera, with >70% of genera and species distributed in Asia. Asian Sonerileae are taxonomically intractable with obscure generic circumscriptions.

 (Gesneriaceae), a new species from central Vietnam.

, a new species of Gesneriaceae from central Vietnam, is described and illustrated here. The new species is most similar to by sharing peduncles up to 22 cm long, bracts 2, zygomorphic, yellow flowers with tubular corolla, stamens 4 with two pairs of coherent anthers and capsules up to 6 cm long. It mainly differs from the latter by the combination of some morphological characters of leaves (shape, base, apex and margin), size of calyx lobes, indumentum of corolla tube and inner surface of three lower corolla lobes.