Publications by authors named "Trung-Kien Nguyen"

Article Synopsis
  • The study aimed to compare the clinical, radiological, and laboratory features of newly diagnosed smear-positive pulmonary tuberculosis in elderly patients (65+) versus younger patients in Vietnam.
  • Out of 183 patients analyzed, those aged 65 and older showed differences in symptoms and X-ray findings, with younger patients more likely to experience night sweats and cavitation lesions, while elderly patients experienced more muscle/joint pain and pulmonary fibrosis.
  • The research highlights the need for age-specific considerations in diagnosing and treating tuberculosis, indicating that tailored approaches could improve patient outcomes based on age-related differences.
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Aim: To determine the rate of prediabetes among and the pre-transplant plasma high-sensitivity C-reactive protein (hs-CRP) value predictive of prediabetes in patients during their first year post-living donor kidney transplant.

Methods: A total of 538 patients underwent living donor kidney transplantation between January 2018 and December 2020, 413 of whom met the inclusion criteria for this study. All patients underwent oral glucose tolerance tests (OGTTs) with 75 g glucose/200 mL solution, starting 3 months post-transplant and repeating the test every 3 months for the first year.

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Objectives: To detect clusters of dengue hemorrhagic fever in an urbanized district of Hai Phong City, Vietnam using Poisson space-time retrospective and prospective analysis.

Methods: A cross-sectional and retrospective study analyzed dengue surveillance data in the period from January 01, 2018, to December 31, 2022. Spatial-temporal scanning statistics were performed using the free software SatScan v10.

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The study aims to explore the potential for transplacental transmission of SARS-CoV-2, focusing on its pathophysiology, placental defense mechanisms, and the clinical implications for maternal and neonatal health. A comprehensive review of the current literature was conducted, analyzing studies on SARS-CoV-2 infection in pregnancy, the expression of key viral receptors (ACE2 and TMPRSS2) in placental cells, and the immune responses involved in placental defense. The review also examined the clinical outcomes related to maternal and neonatal health, including adverse pregnancy outcomes and neonatal infection.

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  • The study aimed to identify how common infections are among Vietnamese children with gastrointestinal symptoms and what factors might increase their risk.
  • It involved 246 children under 16 who underwent testing, revealing that about 81.3% had an infection, with older children being at a higher risk and factors like poor hand hygiene contributing significantly.
  • Key findings indicate that children with infected had different symptoms and complications and that proper handwashing can notably lower the chances of getting infected.
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There have been many studies on the adverse effects of coronavirus disease 2019 (COVID-19) vaccines but the urinary incontinence after COVID-19 vaccination is rare. Here, we report an 8-year-old boy presented to outpatient department, Thai Binh University of Medicine Hospital, Thai Binh, Vietnam with complaints of urinary incontinence for the past 2 weeks, following the first dose of the messenger RNA vaccine. He had no other abnormalities in clinical and laboratory exams.

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This study attempted to improve the photocatalytic activity of zinc oxide (ZnO) semiconductors in the visible light region by introducing the co-doping of carbon (C) and tantalum (Ta) to ZnO (ZTC) using a simple hydrothermal method with the respective precursors. The obtained uniform ZTC nanoparticles with an average crystal size of 29.30 nm (according to Scherrer's equation) revealed a redshift with a decrease in bandgap () from 3.

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  • * Conducted from September 2019 to December 2021, the study analyzed 33 patients, revealing that while motor and sensory nerve conduction tests were normal, repetitive nerve stimulation showed positive responses in 66.7% of cases.
  • * The findings emphasize the need for nerve conduction studies in diagnosing myasthenia gravis, as distinct clinical symptoms like ptosis were common, and a significant relationship was observed between antibody levels and nerve test outcomes.
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Background: Hyperactive coagulation might cause dangerous complications such as portal vein thrombosis and pulmonary embolism after mesenchymal stem/stromal cell (MSC) therapy. Tissue factor (TF), an initiator of the extrinsic coagulation pathway, has been suggested as a predictor of this process.

Methods: The expression of TF and other pro- and anticoagulant genes was analyzed in xeno- and serum-free manufactured MSCs.

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Using the three-dimensional discrete element method, we numerically investigate the collapse dynamics and deposition morphology of low-viscocohesive granular columns on a rough-horizontal plane by systematically varying a broad range of values of the initial column aspect ratio, cohesive stress, and liquid viscosity. The results show that the kinetic energy, half runout time, and runout distance increase with increasing the initial column aspect ratio but decrease with increasing the cohesive and viscous effects of the binding liquid, while the toe angle and deposit height decrease with increasing the aspect ratio and increase with increasing cohesive stress and liquid viscosity. Remarkably, by defining a dimensionless scaling number that incorporates the Bond number and initial column aspect ratio, this allows us to nicely describe the kinetic energy, half runout time, deposition height, runout distance, and toe angle.

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Eu-doped phosphors have been much attractive owing to their narrow-band red emission peak at 610-630 nm with high color purity; however, the weak and narrow absorption band in the NUV region limits their applications. Doping a higher amount of Eu ions into a non-concentration quenching host could be key to enhancing the efficiency of the absorption value and emission intensity. Hence, the design of Eu-heavily doped phosphors with a suitable host lattice is key for applications.

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Phosphor-converted white light-emitting diodes (WLEDs) have received significant attention; however, the leaked light from their blue InGaN chips has an undesirable effect on human health. Hence, it is necessary to develop red, green, and blue-emitting phosphors, which can be excited by an NUV chip instead of a blue chip. Herein, green-emitting ZnO:Cu phosphors have been successfully synthesized by a simple and facile thermal diffusion method.

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Introduction: Hypertension, a major health concern, is associated with significant mortality and disease burden worldwide, including Vietnam. Comprehensive interventions targeting medication, lifestyle modifications, dyslipidemia (DLP), and microalbuminuria (MAU) are vital for effective hypertension management and reducing the risk of cardiovascular disease complications (CDV). While medication interventions have proven efficacy, the evidence regarding the effectiveness of community-based health education interventions in managing DLP and MAU is limited.

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Introduction: Chronic low-grade inflammation (LGI) plays a role in the pathogenesis of gestational diabetes mellitus (GDM). LGI, on the one hand, promotes insulin resistance and at the same time, affects fetal development. The study aimed to use clinically feasible means to evaluate the association between maternal LGI and maternal insulin resistance and fetal growth indices by ultrasound in the third trimester.

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Background: Identification of HER2 protein overexpression and/or amplification of the gene are required to qualify breast cancer patients for HER2 targeted therapies. hybridization (ISH) assays that identify gene amplification function as a stand-alone test for determination of HER2 status and rely on the manual quantification of the number of genes and copies of chromosome 17 to determine amplification.

Methods: To assist pathologists, we have developed the uPath HER2 Dual ISH Image Analysis for Breast (uPath HER2 DISH IA) algorithm, as an adjunctive aid in the determination of gene status in breast cancer specimens.

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We study phase transition properties of the two-dimensional q-state clock model by an extensive Monte Carlo simulation. By analyzing the Binder ratio and its temperature derivative, we confirm that the two-dimensional q-state clock model exhibits two distinct Kosterlitz-Thouless phase transitions for q=5,6 but it has one second-order phase transition for q=4. The critical temperatures are estimated quite accurately from the crossing behavior of the Binder ratio (for q<5) and from negative divergent dips of the derivative of the Binder ratio (for q≥5) around these critical points.

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Penetration of intruders into granular packings is well described by separately considering the dry or wet case of granular environments in previous experiments and simulations; however, the unified description of such penetration depth in these two granular media remains elusive due to lacking clear explanations about its origins. Based on three-dimensional discrete element method simulations, we introduce a power-law fitting form of the final penetration depth of a spherical intruder with low velocity vertically penetrating into dry and wet granular packings, excellently expressed on a master curve as a power-law function of a dimensionless impact number that is defined as the square root of the ratio between the inertial stress of the intruder and the linear combination of the mean gravitational stress and the cohesive stress exerted on each grain in the packings, as a remarkable extension of the inertial number in dry granular flows. This scaling robustly provides physical insights inherent in the unified description of the material properties of granular packings and the impactor penetration conditions on the final penetration depth in the impact tests, providing evidence of impact properties in different disciplines and applications in science and engineering.

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Background And Aim: A low serum prealbumin concentration is common in maintenance hemodialysis patients with hepatitis B and C and may be associated with mortality. In this study, we assessed Department of Nephrology and Hemodialysis predictive value of a low serum prealbumin concentration on mortality in HD patients using reused low-flux dialyzers who were infected with hepatitis B and/or C virus.

Methods: We used serum prealbumin levels to predict the long-term mortality of 326 hemodialysis patients.

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Introduction And Importance: A very rare case with presence of both esophageal and gastric cancers raised questions on how to perform optimal surgery for such cases. To date, reports on experimental surgery strategies for these rare cases remained sparse in the literatures.

Case Presentation: A 61-year-old male patient having epigastric abdominal pain and swallowing difficulties for a month prior to the hospital.

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Cyanobacteria are photosynthetic microorganisms with widespread diversity and extensive global distribution. They produce a wide variety of bioactive substances (e.g.

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Background: Pneumoperitoneum and Trendelenburg position in laparoscopic surgeries could contribute to postoperative pulmonary dysfunction. In recent years, intraoperative lung-protective mechanical ventilation (LPV) has been reportedly able to attenuate ventilator-induced lung injuries (VILI). Our objectives were to test the hypothesis that LPV could improve intraoperative oxygenation function, pulmonary mechanics and early postoperative atelectasis in laparoscopic surgeries.

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Recent successes in Generative Adversarial Networks (GAN) have affirmed the importance of using more data in GAN training. Yet it is expensive to collect data in many domains such as medical applications. Data Augmentation (DA) has been applied in these applications.

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Objectives: To investigate clinical and histopathological characteristics of Vietnamese patients with thymoma and myasthenia gravis (MG), and the outcomes of surgical management using video-assisted thoracoscopic surgery (VATS) thymectomy.

Methods: A prospective study was carried out on 61 patients undergoing VATS thymectomy for MG class I, IIA with thymoma in the period from 10/2013 to 5/2019. The WHO histopathological classification, Masaoka's stages and MG grading using the guidelines of the Medical Scientific Advisory Board of the Myasthenia gravis foundation of America (MGFA) were used.

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Background: Although stem cell transplantation has been successfully performed for cerebral palsy (CP) related to oxygen deprivation, clinical trials involving the use of stem cell transplantation for CP related to neonatal icterus have not been reported. The aim of this study was to evaluate the effectiveness of transplantation of autologous bone marrow mononuclear cell (BMMC) for improving gross motor function and muscle tone in children with CP related to neonatal icterus.

Methods: This open-label, uncontrolled clinical trial, which included 25 patients with CP related to neonatal icterus who had a Gross Motor Function Classification System (GMFCS) score between level II and level V, was conducted between July 2014 and July 2017 at Vinmec International Hospital (Vietnam).

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Background: Quality of life (QOL) is an important factor in evaluating the effectiveness of treatment in children with cerebral palsy (CP). The aim of this study was to evaluate the effects of autologous bone marrow mononuclear cells (BM MNCs) on the QOL of children with CP.

Methods: From December 2015 to December 2016, 30 children with CP aged from 2 to 15 years received two intrathecal infusions of BM MNCs, one at baseline and the other 3 months later, at Vinmec International Hospital.

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