[Pharmacodynamics and results of a clinical trial of nitrogranulong, a new Soviet long-acting preparation of nitroglycerin].

In the USSR, the Research and Production Association "Vitamins" and the Department of Pharmacology, All-Union Research Institute of Medicinal Plants were the first to develop commercial processes for manufacturing trinitroglycerol microgranules on the basis of the raw material available in this country and to design the new long-acting drug Nitrogranulong. Experimental examinations revealed that Nitrogranulong showed the same bioavailability as Nitro-Mack-Retard and sustac, produced a prolonged coronarolytic effect, and caused the hemodynamic and ECG changes typical of trinitroglycerol. The agent was found to be low toxic and well tolerated in a dosage form.

[The importance of food and drug plant factors in the combined treatment of patients with type-II diabetes mellitus].

A study was made of the effect of natural (vegetable dish) and refined (food methylcellulose--MC-100 and citrus pectin) vegetable fibers and Arfazetin (antidiabetic species, USSR) on the level of glucose, immunoreactive insulin (IRI), C-peptide, glucagon and gastrin in the blood of 41 patients with type II diabetes mellitus. These parameters were investigated on an empty stomach, 1, 2 and 4 h after breakfast I with a standard set of foodstuffs and minimum content of nutritive fibers. Similar investigations were conducted after intake of the same breakfast I in combination with various vegetable components.

[Arfazetin in the treatment of diabetes mellitus].

Hypoglycemic activity of arfazetin, a Soviet antidiabetic species of medicinal plants, was studied in 32 patients with diabetes mellitus, types I and II. Arfazetin was administered to patients with diabetes mellitus, type I, in combination with a diet and an adequate dose of insulin. All the patients with diabetes mellitus, type II, were given infusion in addition to a diet and hypoglycemic drugs.

[Pharmacological properties of inulicin, a sesquiterpene lactone from Japanese inula].

Inulicin is a sesquiterpene lactone obtained from Inula Japonica L. (Compositae) possesses a fairly wide spectrum of pharmacological action. In doses from 5 to 60 mg/kg it exerts a certain stimulant action on the central nervous system and smooth muscles of the intestine, displays an anti-inflammatory and anti-ulcer activity on pathological models of different genesis, and has capillary-strengthening diuretic properties.