Publications by authors named "Truc T Ly"

Preoperative identification of causal organism(s) is crucial for effective prosthetic joint infection treatment. Herein, we explore the clinical application of a novel metatranscriptomic (MT) workflow, CSI-Dx, to detect pathogens associated with prosthetic joint infection. MT provides insight into transcriptionally active microbes, overcoming limitations of culture-based and available molecular methods.

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Article Synopsis
  • The study highlights the challenge of pathogen transmission from contaminated surfaces in healthcare settings, even with regular cleaning protocols.
  • Researchers analyzed high-touch surfaces using advanced sequencing techniques to evaluate the effectiveness of cleanSURFACES® technology in reducing microbial contamination in an Emergency Department and an Oncology Ward during the COVID-19 pandemic.
  • Results showed that while overall microbial richness remained unchanged, the composition of microbial communities shifted significantly post-intervention, indicating that cleanSURFACES® combined with routine disinfection can improve surface hygiene in hospitals.
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As one of the top public health challenges outlined by the Centers for Disease Control (CDC), estimates report that hospital acquired infections (HAIs) claim the lives of 99,000 Americans and cost healthcare providers over $28 billion each year. In addition to underlying conditions related to age, elderly patients in long-term care facilities are at an elevated risk of acquiring HAIs. A large percentage of HAIs is attributable to contaminated surfaces and medical devices.

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