[Persistent viruses in serological diagnosis of HIV infection].

Specific antibodies to persistent viruses (CMV, EBV, HBV) were detected by ELISA in groups of HIV-infected patients and persons showing indefinite results of the immunoblotting test for HIV-1 antigens, on the one hand, and in HIV-seronegative donors and patients with clinical manifestations of viral infection (CMVI) on the other. The findings indicate that the persons with indefinite immunoblotting test results show elevated blood CMV and HBV antigen levels than in the matched group of seronegative donors. This fact suggests that persistent viral infections might involve in the formation of an indefinite pattern when the sera were tested for HIV.

[A study of sera positive and doubtful for antibodies to the human immunodeficiency virus for the presence of HTLV-I-specific antibodies].

The results of examinations for the presence of antibody to HTLV-I of 205 sera which were positive or indefinite (doubtful) with regard to HIV are presented. No evidence indicating simultaneous infection with HIV and HTLV-I viruses in 18 HIV-positive subjects was obtained. Antibodies to gag-proteins p19 and p28 HTLV-I were detected in one serum showing primary reactivity in screening for HIV antibodies.

[Disorders of the immune system in benign lesions and cancer of the breast].

Immunologic vigor was studied in 225 cases of breast cancer at various stages, 99 patients with benign lesions of the breast and 154 healthy donors. The parameters of cell-mediated immunity under study included total, active and neuraminidase T-lymphocyte levels, concentration of T-lymphocyte subsets (Tm, T gamma, theophylline--sensitive and theophylline--resistant) and their profile, functional activity of lymphocytes in blastogenic reaction with PHA and natural killer levels. Also, such humoral immunity indexes as B-lymphocytes and immunoglobulins A, M and C were evaluated.

[Disorders of immune homeostasis in patients with tumors of the gastrointestinal tract].

To study immune homeostasis status and to improve the diagnostic value of immunological tests in healthy donors and patients with benign and malignant gastrointestinal tumors, 13 clinico-immunological parameters were identified and measured simultaneously in most of the examinees. A new method of analysis of clinico-immunological information based on stage-by-stage visual evaluation of data shown on dispersion programs and identification of areas corresponding to "normal" immune homeostasis is suggested. Data obtained simultaneously from blastogenic reaction of lymphocytes, cytotoxic test for levels of natural killers in blood and tests for determining subpopulational levels of T-lymphocytes were shown to be diagnostically valuable.

[Block of NK cell activity by ICO-11 monoclonal antibodies].

Antigen expression determined by ICO-11 monoclonal antibodies was studied on leukemia cells from bone marrow, blood cells from patients with lymphoproliferative diseases and natural killer (NK) cells responsible for natural resistance. ICO-11 monoclonal antibodies were shown to recognize the antigen expressed on NK-cells, predecessors of T-cells (thymocytes), myelomonocytes (myeloblasts, monoblasts) and to block NK-cell activity.

[Effect of Brucella abortus on growth of ovarian granulosa cell carcinoma].

Live brucellosis vaccine Brucella abortus administered intraperitoneally, intravenously, subcutaneously or into the tumorous node inhibits the growth of granular cell ovarian carcinoma OC-1-72. The inhibitory effect depends on the B. abortus dose and tumor size.

[Quantitative changes in the cellular makeup of the spleen in mice infected with the Rauscher leukemia virus and Brucella abortus].

Changes in the absolute number of splenic cells of mice infected with Rauscher leukemia virus (RLV) and a day later--with living Brucella (BA) were studied. The increase in the absolute number of splenic cells of mice infected with RLV + BA was initially caused by the lymphoid tissue reaction to Brycella and then by the development of leukemia. The number of reticular cells in the spleen appeared to be larger than the control (RLV) within all observation periods; the number of basophilic normocytes amounted to the control, but an increase in the erythroblasts number was noted a week later and reached the control level by the 30th day, practically being unchanged subsequently.

[Increase in the content of thymus hormone sensitive rosette-forming cell precursors in the spleen of mice vaccinated against smallpox].

Smallpox vaccine injection to 2-month-old C57BL/6j female mice caused during the first days significant rise in the number of precursor cells of rosette-forming lymphocytes, sensitive to the differentiating thymus extract effect. The number of these cells returned to the normal level by the 10th day after vaccination.

Body temperature and tumor virus infection. I. Tumorogenicity of Rous sarcoma virus for reptiles.

Rous sarcoma virus (RSV) was oncogenic for the following nine species of reptiles representing 6 families from Chelonia and Squamata orders: family of Testudinidae: 1. Testudo horsfieldi, family Agamidae: 2. Agama sanguinolenta; 3.

The effect of Trichinella spiralis on graft-versus-host reaction, transplantation immunity and antibody formation.

The effect of Trichinella spiralis in different phases of infection on transplantation immunity, the ability of lymphocytes to induce graft-versus-host reaction, on antibody and plaque-forming cell production was studied. In certain phases of Trichinella spiralis beginhing from the first days of infection and during 40 days significant suppression of transplantation immunity was observed. Thus, on the 24th day of infection skin allograft necrosis occurred much later (26.

[Effect of Trichinella spiralis infection on the development of Rauscher leukemia].

The influence of Trichinella spiralis on the course of Rausher leukemia in mice was studied. Inoculation of mice with Trichinella spiralis larvae 15, 16 and 30 days before infection with Rausher leukemia virus was shown to stimulate splenomegaly, whereas preinoculation of Rausher leukemia virus at 6, 12 and 18 days before infection with Trichinella spiralis resulted in inhibition of splenomegaly. Under the experimental conditions used, no effect of T.