Publications by authors named "Troy M Sofinowski"
Article Synopsis
- Researchers studied cats with feline interstitial cystitis to identify protein expression abnormalities in their urothelium and compared it to human interstitial cystitis cases.
- Analysis involved examining biopsies from 8 affected cats and 7 healthy controls using immunohistochemistry, revealing significant differences in protein expression patterns.
- The findings indicated that a majority of feline cystitis samples showed abnormal protein expression, indicating similarities between feline and human interstitial cystitis mechanisms, thus supporting the cat model for future research.
Purpose: Chondroitin sulfate (Stellar Pharmaceuticals, London, Ontario, Canada), which is less expensive and more inert than heparinoids, hyaluronan or pentosan polysulfate, has been introduced to restore the barrier function lost due to epithelial dysfunction in interstitial cystitis cases. To our knowledge chondroitin sulfate binding to damaged bladder as a function of the urinary pH range, its efficacy in restoring the bladder permeability barrier and the capacity of the damaged bladder to bind chondroitin sulfate have not been determined previously.
Materials And Methods: Chondroitin sulfate binding to bladder urothelium was investigated quantitatively using chondroitin sulfate highly labeled with Texas Red(R) and quantitative fluorescence microscopy in a mouse model of urothelial acid damage.
Reactive oxygen species are formed as by-products of mitochondrial aerobic respiration, as induced products upon exposure to certain environmental/exogenous agents (e.g. ionizing radiation), or as intended products during the immune response against invading foreign microbes.
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