Publications by authors named "Troy G Abram"
The extracellular region of the complement receptor of the Ig superfamily (CRIg) binds to certain C3 cleavage products (C3b, iC3b, C3c) and inhibits the alternative pathway (AP) of complement. In this study, we provide further insight into the CRIg protein and describe two CRIg mutants that lack multiple lysine residues as a means of facilitating chemical modifications of the protein. Structural analyses confirmed preservation of the native CRIg architecture in both mutants.
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- The bacterium causing Legionnaires' disease uses many specialized proteins to help it reproduce within immune cells, with some of these proteins regulating others.
- One specific metaeffector, now renamed MesI (previously Lpg2505), is crucial for the bacterium's growth when paired with another effector called SidI, which disrupts protein production in host cells.
- Researchers found that MesI can inhibit SidI's interference with protein translation and discovered that SidI also has a new enzymatic function, enhancing our understanding of how this bacterium replicates intracellularly.