Publications by authors named "Troy D Fisher"
Article Synopsis
- Organ transplant recipients on immunosuppressants have a weakened ability to respond to infections, including SARS-CoV-2, but their antibody responses may still be effective.
- A new mass spectrometry technique called Ig-MS was used to compare immune responses to COVID-19 between transplant recipients and immunocompetent controls at a single point and over a month after diagnosis.
- The study found no significant differences in antibody characteristics like titer, clonality, or glycan composition between the two groups, suggesting that the immune response evolution in transplant recipients resembles that of immunocompetent individuals.
Scarcity of high-quality organs, suboptimal organ quality assessment, unsatisfactory pre-implantation procedures, and poor long-term organ and patient survival are the main challenges currently faced by the solid organ transplant (SOT) field. New biomarkers for assessing graft quality pre-implantation, detecting, and predicting graft injury, rejection, dysfunction, and survival are critical to provide clinicians with invaluable prediction tools and guidance for personalized patients' treatment. Additionally, new therapeutic targets are also needed to reduce injury and rejection and improve transplant outcomes.
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