Bacteriostatic and biological stimulation effect of Mepitel on experimental burns on the skin of rats.

This study was conducted on 200 white Wistar rats weighing about 200 g each. The animals were divided into two equal groups--an experimental one, with Mepitel (SCA Mölnlycke) dressings, and a control group with cotton gauze dressings. Microbiological and histological examinations and measurements of the wounds made on the 3rd, 7th, 14th, 21st and 28th days after the 3rd-degree heat burn was inflicted using the standard method.

Tactics of sparing activity during the acute period of severe burns.

The authors make an analysis of the acute period and treatment of severe burns affecting over 50% of body surface. In our cases we used a SAPEX fluid bed. All patients were surgically treated after the acute period.

[An experimental study of chemical necrectomy in chemical injuries of the skin].

The authors studied experimentally the morphological changes of injuries and the surrounding areas after a skin chemical injury caused by sodium hydroxide, sulphuric acid and chlorhydric acid under the influence of acidic necrolytics--40% benzoic acid and 40% salycilic acid in unguentus. The necrolytics are applied on the injured areas immediately upon getting the wound or on the 4th day thereafter, while the morphological study is carried out after getting off the necrosis. It has been established that the necrolysis in the case of sodium hydroxide was not effected by the 28th day.

[Methods for the experimental study of the area around a traumatic skin wound].

The author describes the methods for experimental study of the area around a traumatic skin wound, which up to now have been neglected by the hospital doctors and the investigators. The choice of the experimental animals and the methods for the preliminary preparatory work with them have been described. The author in details specifies the ways of injuring the skin--by thermal burn, mechanical crushing and combination of both, chemical injury and incision wound.

[The effect of temporary skin substitutes on the area around the wound following an experimental thermal burn of the skin].

The effect of temporary skin resurfacing on processes developing in the skin surrounding post-thermal-burn wounds is morphologically studied in experiment. The burned wound region and perilesional area are immediately covered by a fresh allograft, xenograft, Ampoxen, Pharmexplant and Deflamol ointment. Tissue specimens for histological evaluation are taken within 3, 7 and 14 days.

[The experimental and clinical use of neprolizin in thermal burns of the skin].

Morphological skin changes within the focus of lesion and in the perilesional area are studied against the background of local application of the Bulgarian enzyme preparation Neprolyzin. The experimentally induced injury includes thermal burn, mechanical crushing (conquassatio), and combination of the two. The drug is administered immediately after the trauma, or on the fourth post-injury day, with the studies performed after 4-day-long treatment.

[The area around the wound in experimental chemical injuries to the skin].

This is an experimental assessment of the morphological patterns of skin in the area surrounding wounds, produced by exposure to sodium base, sulfuric acid and hydrochloric acid. The changes are followed up from 6th hour to 28th post-injury day, and compared with those in the skin surrounding thermal burns using the same experimental setup. The differences in healing processes, both by comparison with the control group, and between the individual chemical agents, are insignificant.

Regulation of traumatic skin wound healing by influencing the process in the neighbouring zone of the wound.

After the burn, the authors immediately applied the albuminous hydrolysate Hydropot, a propolis-urea ointment and Trypsin compresses (3,500 E) to the burned area and its vicinity, and repeated this procedure for several days. Samples for histological examination were taken after the animals' decapitation every 2 hrs. and on the 3rd, 5th and 14th post-injury days.