Publications by authors named "Trong Toan Nguyen"
Background: Preterm infants are more likely to experience severe respiratory syncytial virus (RSV) disease compared to term infants. The reasons for this are multi-factorial, however their immature immune system is believed to be a major contributing factor.
Methods: We collected cord blood from 25 preterm (gestational age 30.
Article Synopsis
- Preterm infants are more vulnerable to severe infections than full-term infants, possibly due to their ability to respond to pathogens, with limited research on their viral response specifically.
- The study examined immune responses in cord blood mononuclear cells from preterm and term infants, comparing their reactions to various Toll-like receptor (TLR) agonists, revealing similar baseline TLR expression but different activation patterns.
- While both preterm and term infants displayed comparable responses, preterm infants had increased monocyte activation to certain bacterial stimuli, but did not match the higher levels of immune response seen in adults, indicating a need for further research to address infection risks in preterm infants.
Efficacy, safety, and immunogenicity of an inactivated, adjuvanted enterovirus 71 vaccine in infants and children: a multiregion, double-blind, randomised, placebo-controlled, phase 3 trial.
Trong Toan Nguyen Cheng-Hsun Chiu Chien-Yu Lin Nan-Chang Chiu Po-Yen Chen Van Luan Nguyen Thi Thanh Thao Nguyen
Lancet
April 2022
Background: Children are susceptible to severe or fatal enterovirus 71 (EV71) infections. We aimed to evaluate the efficacy, safety, and immunogenicity of EV71vac, an aluminium phosphate-adjuvanted inactivated EV71 vaccine in children aged 2-71 months.
Methods: We did a randomised, double-blinded, placebo-controlled, phase 3 trial at five hospitals in Taiwan and two in Vietnam.