Investigation of UV Light-Promoted Synthesis of α-Sulfonyl Amides from -Sulfonyl Ynamides.

UV light-promoted synthesis of α-sulfonyl amides from -sulfonyl ynamides without any additives is reported. The reaction proceeds through a radical chain mechanism involving the photoinduced cleavage of the nitrogen-sulfur bond and addition of an electrophilic sulfonyl radical to the triple bond of the ynamide followed by β-fragmentation of the sulfonyl group leading to a ketenimine hydrated upon workup. This highly efficient rearrangement leads, after acidic treatment, to a wide range of α-sulfonyl amides in high yields.

An oriented phase-II trial of D-Trp6-LH-RH in patients with prostatic carcinoma.

An oriented phase II trial of D-Trp6-LH-RH was conducted according to Gehan's statistical method on 25 patients suffering from prostatic carcinoma. LH and testosterone serum levels decreased rapidly. Pain disappeared during the third month in 14 out of the 21 patients and markedly decreased in 5.

Density dependence of the maximal expiratory flow volume curves in normal and asthmatic children.

We have studied the maximal expiratory flow volume curves with air and with an 80% helium-oxygen mixture, using 12 normal and 33 asthmatic children chosen according to clinical, functional and immunological criteria. In the normal children, the average delta Vmax (difference between the maximal flow in HeO2 and in air at corresponding lung volumes) was 49% and was similar from 60% to 20% of vital capacity. The iso flow volume (lung volume level at which the HeO2 and air flow volume curves intersect) was 3% of vital capacity.

[Comparative study of a vagolytic and a beta 2 sympathomimetic drug on the respiratory function of the asthmatic patient].

The authors compared the effects of a synthetic vagolytic drug, the SCH 1000, and a beta2 sympathicomimetic one (Fenoterol) in two groups of control children (n = 11) and two groups of asthmatic children (n = 23). They studied the following parameters, flow volumes curves, steady state lung diffusing capacity and the blood gases. No difference of efficiency was found between the two types of bronchodilators although the graphic modification of flow volumes curves was different after Fenoterol and after SCH 1000.

[Effect of bronchodilators on density dependence of expiratory flow-volume curves. An attempt to localize bronchodilators site of activity (author transl)].

In order to localize bronchodilators site of activity we studied the maximal expiratory flow-volume curves breathing air and 80 percent-20 percent helium-oxygen mixture in 11 normal and 23 asthmatic children. We measured delta Vmax. 60 percent TLC.