Evaluation of [Cu]Cu-NOTA-PEG-H-Tz for Pretargeted Imaging in LS174T Xenografts-Comparison to [In]In-DOTA-PEG-BisPy-Tz.

Pretargeted nuclear imaging for the diagnosis of various cancers is an emerging and fast developing field. The tetrazine ligation is currently considered the most promising reaction in this respect. Monoclonal antibodies are often the preferred choice as pretargeting vector due to their outstanding targeting properties.