Publications by authors named "Troels Edsen"
Object: The nitric oxide system has been linked to the pathogenesis of aneurysmal subarachnoid hemorrhage (SAH). The authors performed a case-control study to investigate the association between SAH and common genetic variants within the endothelial nitric oxide synthase gene (NOS3).
Methods: Three hundred thirty-three Caucasian SAH patients and 498 controls were genotyped for the -922A > G (rs 1800779), -786T > C (rs2070744), and 894G > T (rs1799983) single nucleotide polymorphisms and the intron-4 27-bp variable number of tandem repeats polymorphism (27-bp-VNTR).
Article Synopsis
- This study investigates the role of circulating levels of asymmetrical dimethylarginine (ADMA) and the arginine:ADMA ratio in relation to mortality and cerebral vasospasm in patients after subarachnoid hemorrhage (SAH).
- Among 111 patients observed over 15 days, a significant difference in 30-day mortality rates was found based on the arginine:ADMA ratio, with low ratios showing the highest mortality risk.
- The findings indicate that the plasma arginine:ADMA ratio can be a predictor of survival post-SAH, highlighting the relationship between cerebral blood flow dynamics and the nitric oxide system.
Objective: The intron 16 insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene has been associated with rupture of intracranial aneurysms, but the effect of haplotypes within ACE has not been studied. This study investigated whether ACE haplotypes including the I/D polymorphism are associated with aneurysmal subarachnoid hemorrhage.
Methods: The hypothesis was tested with a case-control design in 176 patients with aneurysmal subarachnoid hemorrhage and with 498 hospital controls.