Publications by authors named "Trivikram Gaddapara"
Primary graft dysfunction (PGD) is a severe form of acute lung injury, leading to increased early morbidity and mortality after lung transplant. Obesity is a major health problem, and recipient obesity is one of the most significant risk factors for developing PGD. We hypothesized that T-regulatory cells (Tregs) are able to dampen early ischemia-reperfusion events and thereby decrease the risk of PGD, whereas that action is impaired in obese recipients.
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- PKD is a family of three kinases (PKD-1, -2, and -3) that regulate key biological processes like cell growth, migration, and survival; PKD1 is especially crucial for wound healing and tumor development in mice.
- Unlike in mice, PKD1 is absent in human skin cells (keratinocytes), leading to differences in how PKD isoforms function in humans, particularly regarding cell growth responses.
- The study shows that PKD2 promotes growth in human keratinocytes, while PKD3 is essential for cell proliferation; loss of PKD3 leads to severe proliferation issues and an inability to properly regenerate tissue, highlighting the complexity of PKD signaling in skin health.
Hair follicle morphogenesis is initiated by a dermal signal that induces the development of placodes in the overlying epithelium. To determine whether WNT signals are required for initiation of follicular development, we ectopically expressed Dickkopf 1, a potent diffusible inhibitor of WNT action, in the skin of transgenic mice. This produced a complete failure of placode formation prior to morphological or molecular signs of differentiation, and blocked tooth and mammary gland development before the bud stage.
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