Publications by authors named "Tristan Loveday"
Article Synopsis
- Cholangiocarcinoma is a type of cancer affecting the bile ducts, often linked to chronic inflammation and fibrosis, and this study investigates the usefulness of the APRI score in predicting surgical outcomes for patients.
- Data from 152 patients who had surgery at the Mayo Clinic were analyzed, looking for correlations between the APRI score and various clinical factors, with a focus on survival rates.
- The results showed no significant relationship between the APRI score and demographic or tumor characteristics, indicating it is not a reliable prognostic tool for predicting post-surgical outcomes in cholangiocarcinoma patients.
We investigated the clinicopathologic features of 5 follicular lymphomas (FLs) that transformed (tFL) morphologically to diffuse large B-cell lymphomas (DLBCLs) and had a primary mediastinal large B-cell lymphoma (PMBL)-like gene expression profile (tFL-PMBLsig-pos). None of the tFL-PMBLsig-pos cases arose in the mediastinum, all cases tested had a germinal center B-cell phenotype, 20% were CD30+, 60% CD23+, 80% MAL+, 20% CD200+, and 0% CD273/PDL2+. Whole-exome sequencing detected alterations in genes associated with both FL/DLBCL (CREBBP, KMT2C, KMT2D, ARID1A, HIST1 members, and TNFRSF14) and PMBL (JAK-STAT pathway genes, B2M, and CD58).
View Article and Find Full Text PDFDuctal carcinoma in situ (DCIS) is a risk factor for the subsequent development of invasive breast cancer. High-risk features include age <45 years, size >5 cm, high-grade, palpable mass, hormone receptor negativity, and HER2 positivity. We have previously shown that immune infiltrates are positively associated with these high-risk features, suggesting that manipulating the immune microenvironment in high-risk DCIS could potentially alter disease progression.
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