Publications by authors named "Tristan L A White"
hnRNP A1 is an important RNA-binding protein that influences many stages of RNA processing, including transcription, alternative splicing, mRNA nuclear export, and RNA stability. However, the role of hnRNP A1 in immune cells, specifically CD4+ T cells, remains unclear. We previously showed that Akt phosphorylation of hnRNP A1 was dependent on TCR signal strength and was associated with Treg differentiation.
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- Miscommunication between antiviral and antibacterial signals during respiratory infections can worsen illness and increase death rates.
- Extracellular vesicles (EVs), released from epithelial cells during antiviral responses, hinder the ability of macrophages to fight bacterial infections in the airway.
- This study highlights how these EVs disrupt communication between epithelial cells and macrophages, leading to impaired immune responses and offering new insights into the challenges of immune dysfunction in respiratory coinfections.
The activation and differentiation of CD4 T cells is a complex process that is controlled by many factors. A critical component of the signaling pathway triggered following T-cell receptor (TCR) engagement is the serine threonine kinase Akt. Akt is involved in the control of many cellular processes including proliferation, metabolism, and differentiation of specific T-cell subsets.
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