Publications by authors named "Trisha Sikder"
Article Synopsis
- Aging is a significant risk factor for Alzheimer's disease, and researchers conducted a whole-genome CRISPR screen to find out how neuronal age is regulated.
- They discovered that the neddylation pathway affects both cellular aging and neurodegeneration related to Alzheimer's in human stem cells.
- Blocking neddylation led to more signs of aging and neuron loss, suggesting that targeting this pathway could be a new strategy to slow down Alzheimer's progression.
The differentiation of human pluripotent stem cells (hPSCs) provides access to most cell types and tissues. However, hPSC-derived lineages capture a fetal-stage of development and methods to accelerate progression to an aged identity are limited. Understanding the factors driving cellular age and rejuvenation is also essential for efforts aimed at extending human life and health span.
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