Central venous access device adverse events in pediatric patients with cancer: a systematic review and meta-analysis.

Purpose: To systematically review the proportion and incidence of CVAD-associated complications in pediatric patients with cancer.

Methods: PubMed, Embase, and the Cumulative Index of Nursing and Allied Health Literature were searched from 2012 to 2022. Cohort studies and the control arm of randomized controlled trials, which reported CVAD-associated complications in pediatric patients aged 0-18 years, were included.

Vincristine sulfate liposomal injection for acute lymphoblastic leukemia.

Vincristine (VCR) is one of the most extensively used cytotoxic compounds in hemato-oncology. VCR is particularly important for the treatment of acute lymphoblastic leukemia (ALL), a disease that accounts for approximately one-third of all childhood cancer diagnoses. VCR's full therapeutic potential has been limited by dose-limiting neurotoxicity, classically resulting in autonomic and peripheral sensory-motor neuropathy.