Publications by authors named "Trish A McBride"

Background: Fractures cause significant morbidity, mortality, and use of health care resources. An oral agent that enhances fracture healing could reduce costs and prevent future disabilities. In Phase I studies, ronacaleret, a novel calcium-sensing receptor antagonist, stimulated parathyroid hormone (PTH) release and increased bone formation markers, suggesting that it may act as an effective oral anabolic agent to enhance fracture healing.

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Article Synopsis
  • Vardenafil hydrochloride is evaluated for effectiveness and side effects in men with erectile dysfunction (ED) who did not respond to sildenafil citrate, focusing on its use within 0.25 to 6 hours after taking the medication.
  • A prior study involving 463 men across multiple global locations used daily patient diaries to track attempts at sexual intercourse and erections, comparing vardenafil with placebo.
  • Results from this analysis contribute to understanding vardenafil's success rates and tolerability for users with sildenafil nonresponse, emphasizing individualized dosing options.
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Article Synopsis
  • The study aimed to assess the effectiveness of vardenafil in men who did not respond to sildenafil for erectile dysfunction.
  • The trial involved 463 men and showed that those taking vardenafil experienced significant improvements in erectile function compared to those on a placebo.
  • Results suggested that vardenafil not only doubled the success rates for penetration and intercourse but also was generally safe with minimal side effects.
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