Publications by authors named "Tripto-Shkolnik L"
Article Synopsis
- Elevated growth hormone secretion in acromegaly affects mineral balance and phosphate levels, but their long-term clinical value as a disease marker is unclear.
- A study analyzed data from 61 patients with acromegaly to explore the relationship between baseline serum phosphate levels and disease characteristics over an average of 4.5 years.
- Results showed that higher baseline phosphate levels were linked to larger adenomas, greater risk of invasive tumors, and worse disease outcomes, indicating the importance of monitoring phosphate levels in acromegaly patients.*
Article Synopsis
- - X-linked hypophosphatemia (XLH) is a rare disorder caused by high levels of FGF23, leading to phosphate loss and decreased vitamin D production, while burosumab is a treatment that helps restore phosphate levels by inhibiting FGF23.
- - This post-authorization safety study (PASS) monitors the long-term safety of burosumab in children and adolescents aged 1-17 years, with this first interim analysis focusing on the initial safety outcomes based on registry data.
- - The analysis involved 67 participants, with 37.3% reporting at least one adverse event, primarily musculoskeletal issues; however, there were no serious adverse events or treatment withdrawals, indicating that the safety profile of
Article Synopsis
- Anabolic treatment is necessary for high-risk osteoporosis patients, but the current injectable medications are not well-accepted; this study tests a new oral PTH tablet alternative.
- In a 6-month, double-blind study with 161 postmenopausal women, the oral PTH showed dose-dependent effects on bone markers, with the highest dose (2.5 mg) significantly increasing bone formation markers and decreasing bone resorption markers.
- The 2.5 mg oral PTH tablets improved bone mineral density (BMD) at crucial sites (lumbar spine, total hip, and femoral neck) compared to placebo, and while some mild side effects occurred, no serious adverse events were reported.
Background: Teriparatide (TPTD) should be followed by an antiresorptive to maximize bone mineral density gain and anti-fracture protection. Infrequent zoledronic acid (ZOL) administration has demonstrated effectiveness. The duration of ZOL effect following TPTD is unknown.
View Article and Find Full Text PDFArticle Synopsis
- X-linked hypophosphatemia (XLH) is a rare genetic disorder that causes phosphate wasting in the kidneys and is linked to increased levels of the hormone FGF23; its rarity can lead to delayed diagnosis, worsening patient outcomes.
- The International XLH Registry was launched in 2017 to gather data on XLH patients of all ages, with an interim analysis reporting on 579 participants as of March 2021, highlighting a longer diagnosis time for older adults compared to children.
- Data collected included family histories and genetic testing, revealing that a significant proportion of patients had biological relatives also affected by XLH, while most had a confirmed genetic mutation related to the disorder.
Background: Trabecular bone score (TBS) reflects vertebrae microarchitecture and assists in fracture risk assessment. The International Society of Clinical Densitometry postulates that the role of TBS in monitoring antiresorptive therapy is unclear. Whether changes in TBS correlate with bone resorption measured by bone turnover markers is not known.
View Article and Find Full Text PDFPregnancy- and lactation-induced osteoporosis: a social-media-based survey.
BMC Pregnancy Childbirth
May 2023
Background: Pregnancy- and lactation-induced osteoporosis (PLO) presenting as spinal fractures is rare, and the spectrum of clinical presentation, risk factors and pathophysiology are incompletely understood. The aim of this study was to delineate clinical parameters, risk factors and osteoporosis-related quality of life (QOL) of women with PLO.
Methods: Participants of a social-media (WhatsApp) PLO group and mothers of a parents' WhatsApp group (control group) were offered to fill a questionnaire, including an osteoporosis-related QOL section.
Autonomous finite element analyses (AFE) based on CT scans predict the biomechanical response of femurs during stance and sidewise fall positions. We combine AFE with patient data via a machine learning (ML) algorithm to predict the risk of hip fracture. An opportunistic retrospective clinical study of CT scans is presented, aimed at developing a ML algorithm with AFE for hip fracture risk assessment in type 2 diabetic mellitus (T2DM) and non-T2DM patients.
View Article and Find Full Text PDFUnlabelled: The current study explored the possible utilization in dual-X-ray-absorptiometry scanning (DXA) of the ultra-distal radius (UDR). This region of interest is currently unused and mostly unstudied in this context. The study findings suggest UDR as potential useful region of interest in DXA scanning and warrant further study of the site.
View Article and Find Full Text PDFArticle Synopsis
- X-linked hypophosphataemia (XLH) is a rare genetic disorder characterized by elevated FGF23 levels, leading to phosphate-wasting and various bone-related issues.
- Traditional treatments like oral phosphate and vitamin D supplements don't fully address the root causes or all symptoms of the disease.
- A new study (PASS) is assessing the long-term safety of burosumab, a monoclonal antibody treatment for XLH, using data from a global registry over the next decade.
The COVID-19 pandemic led to fundamental changes in daily routines of children. Our aim was to evaluate the incidence and characteristics of fractures among Israeli children during 2020 compared with 2015-2019. Demographic, clinical data, and incidence rates of fractures in individuals aged < 18 years were derived from the electronic database of Meuhedet Health Services, which provides healthcare services to 1.
View Article and Find Full Text PDFImpaired bone health is a common complication of anorexia nervosa (AN). We aimed to assess longitudinal changes in bone mineral density (BMD) and trabecular bone score (TBS), a measure of bone quality, in female adolescents with anorexia nervosa (AN). We conducted a retrospective longitudinal study of 41 female adolescents with AN who underwent two dual-energy X-ray absorptiometry (DXA) scans.
View Article and Find Full Text PDFArticle Synopsis
- - The study analyzed 20 years of fracture data among Israeli children, collecting information from Meuhedet Health Services, which serves 1.2 million people.
- - A total of 188,283 fractures were recorded, with upper limb fractures being the most common and a higher incidence rate in boys compared to girls.
- - The research found significant trends, including a decrease in fractures in the general Jewish population and an increase among ultra-orthodox Jewish children, while noting seasonal peaks in fractures during spring and autumn.
Bisphosphonates Related Ocular Side Effects: A Case Series and Review of Literature.
Ocul Immunol Inflamm
December 2022
Objective: To describe the clinical features of patients with bisphosphonate related ocular side effects (BROSE).
Methods: The medical records of all patients with BROSE between January 2009 and December 2019 were reviewed.
Results: Nine cases with BROSE were identified.
Objective: To investigate the added value of 1/3 radius (1/3R) for the diagnosis of osteoporosis by spine and hip sites and its correlation with prevalent fractures and predicted fracture risk.
Methods: Fracture Risk Assessment Tool (FRAX) scores for hip and major osteoporotic fractures (MOF) with/without trabecular bone score were considered proxy for fracture risk. The contribution of 1/3R to risk prediction was depicted via linear regression models with FRAX score as the dependent variable-first only with central and then with radius T-score as an additional covariate.
Denosumab discontinuation is associated with rapid reversal of bone turnover suppression and with a considerable increase in fracture risk, including a risk for multiple vertebral fractures (MVF). Long-term follow-up of patients who sustained MVF after denosumab discontinuation has not been reported. This case-series was aimed to provide a long-term follow-up on the management and outcome of denosumab discontinuers who initially presented with multiple vertebral fractures.
View Article and Find Full Text PDFObjective: Seizures following administration of potent bisphosphonates have been reported only sporadically in the medical literature. The rare cases described were often attributed to other precipitating factors such as hypoglycemia, acute infection, or predisposition to post-bisphosphonate hypocalcemia. We review the previous cases and present a new case of suspected seizure episode following zoledronic acid therapy.
View Article and Find Full Text PDFIntroduction: Trabecular bone score (TBS) is a textural index that evaluates bone microarchitecture of the lumbar spine. Our aim was to assess TBS in children with inflammatory bowel diseases and to evaluate correlations with clinical, laboratory and densitometric variables.
Methods: A retrospective study of TBS and areal bone mineral density measurements by dual-energy X-ray absorptiometry (DXA) of children with either Crohn's disease (CD) or ulcerative colitis (UC).
Objective: The number of transgender and gender non-conforming children is on the rise. For these children, the timing of medical intervention is crucial, yet transgender children report poorer overall physical and mental health outcomes compared with their cisgender peers. We aim to describe how paediatricians perceive transgender people.
View Article and Find Full Text PDFArticle Synopsis
- Vertebral fractures can increase significantly after stopping Denosumab (DMAB), particularly among older women.
- In a study of over 3,100 osteoporosis patients, those who discontinued DMAB experienced much higher rates of fractures compared to those who continued.
- The findings highlight the importance of monitoring and managing patients who discontinue DMAB to prevent serious fractures.
Clinical encounters with transgender people seeking hormonal treatment for gender reaffirmation, provide an opportunity, besides engagement in the endocrine dilemmas, to challenge the binary pattern of thinking and reveal many fascinating and complex matters of transgender medicine: human, philosophical and political. The current review of the subject is presented by an endocrinologist engaged in hormonal treatment of transgender people.
View Article and Find Full Text PDFBackground & Aims: Trabecular bone score (TBS) is an emerging technology that provides information regarding bone microarchitecture. A recent study showed that in healthy girls normal TBS (≥1.35) was achieved within the first year post-menarche.
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