Publications by authors named "Triplicane Dwarakanathan Hariharan"
Background: Fused hips with spine stiffness in ankylosing spondylitis (AS) reduce spinopelvic mobility. We aimed to assess spinopelvic mobility pattern and acetabular anteversion in AS after total hip arthroplasty (THA).
Material And Methods: Ninety-four stiff hips in 58 AS individuals (mean age: 37.
Ankylosing spondylitis (AS) is characterized by involvement of the spine and hip joints with progressive stiffness and loss of function. Functional impairment is significant, with spine and hip involvement, and is predominantly seen in the younger age group. Total hip arthroplasty (THA) for fused hips with stiff spines in AS results in considerable improvement of mobility and function.
View Article and Find Full Text PDFThe Influence of Biofilms on Carbapenem Susceptibility and Patient Outcome in Device Associated Infections: Insights Into Phenotype vs Genome-Wide Analysis and Correlation.
Front Microbiol
December 2020
Article Synopsis
- Nosocomial infections, particularly those caused by carbapenem-resistant pathogens, are increasing globally and their ability to form biofilms complicates patient management.
- The study investigates the relationship between biofilm formation, patient outcomes, and carbapenem resistance in isolates from patients in critical care, revealing a negative impact on patient survival associated with stronger biofilm formers.
- Genetic analysis showed specific sequence types of bacteria are linked to biofilm formation and drug resistance, with a unique correlation suggesting that traditional susceptibility tests may not accurately reflect treatment effectiveness due to biofilm environments.
Levonadifloxacin, a recently approved benzoquinolizine fluoroquinolone, exhibits potent in vitro activity against contemporary Staphylococcus aureus isolates and Bengal Bay clone isolates collected from a large Indian tertiary care hospital.
J Antimicrob Chemother
August 2020
Objectives: Levonadifloxacin (WCK 771; IV) and its prodrug alalevonadifloxacin (WCK 2349; oral) are benzoquinolizine fluoroquinolones, recently approved in India for the treatment of acute bacterial skin and skin structure infections with concurrent bacteraemia and diabetic foot infections. Ahead of its market launch, the present study aimed to assess the in vitro activity of levonadifloxacin against contemporary Staphylococcus aureus isolates collected from a large tertiary care hospital in India. Additionally, levonadifloxacin activity was tested against hVISA and Bengal Bay clone MRSA isolates.
View Article and Find Full Text PDFStaphylococcal surface protein sasX is a colonization mediating virulence factor in ST239 methicillin-resistant Staphylococcus aureus (MRSA) strains, which potentially contribute to its successful establishment. We aimed to study the presence and dissemination of sasX in clinical MRSA isolates and among MRSA carriers. A total of 450 nonduplicate clinical MRSA isolates recovered from blood cultures between 2013 and 2017 were included in this study.
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