Primary cutaneous melioidosis - A rare case needing intensive care unit admission.

Background: Melioidosis cases are increasing in Southeast Asia, posing a significant challenge owing to the rising number of diabetic and immune compromised patients. Pneumonia is the most common presentation of melioidosis, while cutaneous melioidosis is rare.

Objectives: We report a case of primary cutaneous melioidosis (PCM) that eventually required intensive care unit (ICU) management.

Dr. Thomas Francis Jr.: A Legacy of Vaccine Innovation and Public Health Advancement.

Dr. Thomas Francis Jr. was an American physician, virologist, and epidemiologist who was a professor of epidemiology at the University of Michigan from 1941 to 1969.

Management of adult sepsis in resource-limited settings: global expert consensus statements using a Delphi method.

Purpose: To generate consensus and provide expert clinical practice statements for the management of adult sepsis in resource-limited settings.

Methods: An international multidisciplinary Steering Committee with expertise in sepsis management and including a Delphi methodologist was convened by the Asia Pacific Sepsis Alliance (APSA). The committee selected an international panel of clinicians and researchers with expertise in sepsis management.

Neonatal Brain Injury Triggers Niche-Specific Changes to Cellular Biogeography.

Preterm infants are at risk for brain injury and neurodevelopmental impairment due, in part, to white matter injury following chronic hypoxia exposure. However, the precise molecular mechanisms by which neonatal hypoxia disrupts early neurodevelopment are poorly understood. Here, we constructed a brain-wide map of the regenerative response to newborn brain injury using high-resolution imaging-based spatial transcriptomics to analyze over 800,000 cells in a mouse model of chronic neonatal hypoxia.

Synthesis of Magnetic Luminescent Nanoparticle FeO@LaF:Eu,Ag@APTES@β-CD, a Potential Carrier of Antimicrobial Drug Ciprofloxacin.

FeO@LaF:Eu,Ag hybrid magnetic luminescent nanoparticles (NPs) were synthesized using a simple co-precipitation method and then functionalized with β-cyclodextrin (β-CD) using (3-aminopropyl)triethoxysilane (APTES). The chemical composition, crystalline nature, particle size, and surface morphology of the FeO@LaF:Eu,Ag@APTES@β-CD NPs were investigated, using powder X-ray diffraction, and high-resolution transmission electron microscopy. The uptake and release profiling of the LaF:Eu,Ag@FeO@β-CD NPs for the hydrophilic drug ciprofloxacin, showed 40 and 85% efficiency, respectively.

Changing Trends of Ralstonia Bacteremia in Patients at a Tertiary Care Center in North India: A 2-Year Retrospective Analysis.

Ralstonia species are recently emerging as pathogens of human importance. This study was performed to assess the distribution of Ralstonia species among bacteremia patients and the clinical and demographical factors of these patients. This retrospective observational study was performed in the Microbiology Department of a tertiary care center in North India from April 2022 to April 2024.

Energy conservation or expense? A possible dilemma under combined stresses of salinity and submergence in rice.

Salinity and flooding are two major production impediments affecting rice cultivation in coastal agro-ecosystems. We investigated how rice plants use two contrasting strategies such as energy conservation (for submergence tolerance) and energy expenditure (for ion exclusion) to adapt to the combined stresses of saline water submergence (SWS). Pot and hydroponic experiments were conducted using four selected rice genotypes carrying Sub1 (Submergence1) and/or Saltol (Salinity tolerance) QTLs in their genetic background and exposed them to salinity and submergence stresses individually and combined under controlled experimental conditions.

A high-resolution hydrodynamics and sediment dataset in the coastline waters of the Northern Bay of Bengal.

Regional Ocean Modeling System (ROMS) - Community Sediment Transport Modeling System (CSTMS) model used to acquire a dataset of physical variables and sediment on the continental shelf of India and countries adjacent to the Northern Bay of Bengal. The high-resolution model resolved the complex bathymetry taken from ETOPO2, forced by COADS climatological winds. Furthermore, the tides are taken from TPXO7 and lateral boundaries from SODA with initial condition from WOA09 and sediment concentration set to zero in the simulation.

Rippled Pattern Basal Cell Carcinoma - A Rare Variant with a Diagnostic Approach.

The rippled pattern of basal cell carcinoma (BCC) is a very uncommon variant and poses a diagnostic challenge. A 52-year-old male presented with an ulcerated lesion over the scalp for 8 years. The wedge biopsy of the lesion showed an infiltrating tumour in the upper dermis and mid-dermis with focal attachment with the epidermis.

PreVenTB trial: protocol for evaluation of efficacy and safety of two vaccines VPM1002 and Immuvac (Mw) in preventing tuberculosis (TB) in healthy household contacts of newly diagnosed sputum smear-positive pulmonary TB patients: phase III, randomised, double-blind, three-arm placebo-controlled trial.

Introduction: Tuberculosis (TB) continues to be one of the deadliest infectious diseases over the centuries, killing more people worldwide than any other single infectious disease. There is an urgent need for additional strategies which can expedite efforts to combat TB including a preventive vaccine. In this endeavour, we have developed a protocol for a multisite, double-blind, placebo-controlled clinical trial in India that aims to evaluate the efficacy and safety of two TB vaccines; namely, VPM1002 and Immuvac () () (MIP) among healthy household contacts (HHCs) of sputum smear-positive pulmonary TB (PTB) patients.

Lipid nanocarrier-based bigel of oil for analgesic and anti-inflammatory applications.

Present study reports analgesic and anti-inflammatory potential of (L.) leaf oil loaded lipid nanocarrier (BLNs)-embedded bigel. BLNs were developed by solvent evaporation technique and were characterised by FESEM, Cryo-TEM, mean diameter, zeta potential, loading efficiency, etc.

Machine learning identifies cytokine signatures of disease severity and autoantibody profiles in systemic lupus erythematosus - a pilot study.

Disrupted cytokine networks and autoantibodies play an important role in the pathogenesis of systemic lupus erythematosus. However, conflicting reports and non-reproducibility have hindered progress regarding the translational potential of cytokines in SLE. This study attempts to address the existing knowledge gap using multiplex cytokine assay and machine learning.

A Short Course of Preoperative Denosumab Injection Followed by Surgery in High-Risk Giant Cell Tumors of the Extremities: A Retrospective Study.

Despite early promising results with denosumab treatment in giant cell tumor of bone (GCTB), recent studies have raised concerns about a high local recurrence rate following preoperative denosumab administration and joint preservation surgery. This retrospective study evaluated data from 25 high-risk GCT patients (Campanacci grade II or III with features like soft tissue extension, pathological fracture, minimal periarticular or subarticular bone) treated with five doses of neoadjuvant denosumab injection followed by either curettage and cementing ( = 13) or joint reconstruction with fibular graft/endoprosthesis ( = 12) between 2014 and 2019. With an average follow-up of 40 months, the study found only one patient of local recurrence.

The effects of deep brain stimulation on sleep: a systematic review and meta-analysis.

Background: Deep brain stimulation (DBS) is a standard treatment for movement disorders, epilepsy, and others, yet its influence on postprocedural sleep quality remains an under-researched topic.

Study Objectives: We performed a systematic review and meta-analysis of all DBS effects on sleep.

Methods: The use of preferred reporting items for systematic reviews and meta-analyses guidelines (PRISMA) was utilized.

Effective adsorption of Cr(VI) from aqueous solution by Mg-Fe LDH supported on orange peel activated carbon: isotherm, kinetic, thermodynamics and mechanism studies.

The toxic Cr(VI) contaminating water released from the metallurgical, dyeing, and electroplating industries is getting worse day by day and is extremely hazardous to human health. Thus, the development of a cost-effective, quick, and efficient adsorbent is highly essential for the Cr(VI) decontamination from wastewater. Herein, a microwave-assisted carbon-based composite called Mg-Fe LDH@OPAC was prepared by assembling Mg-Fe LDH onto orange peel-activated carbon (OAPC).

Aneurysmal Bone Cyst of the Distal Ulna in an Elderly Lady.

Introduction: Aneurysmal bone cyst (ABC) is a rare, benign, cystic, hemorrhagic expansile osteolytic lesion of unknown etiology resembling multiple intraosseous blood-filled spaces mostly seen in the first two decades of life. It accounts for <1% of all bone tumors and the usual sites are the metaphyses of the proximal and distal femur, proximal tibia, and posterior elements of the spine. Affection of other sites is unusual.