Constructing a metadata knowledge graph as an atlas for demystifying AI pipeline optimization.

The emergence of advanced artificial intelligence (AI) models has driven the development of frameworks and approaches that focus on automating model training and hyperparameter tuning of end-to-end AI pipelines. However, other crucial stages of these pipelines such as dataset selection, feature engineering, and model optimization for deployment have received less attention. Improving efficiency of end-to-end AI pipelines requires metadata of past executions of AI pipelines and all their stages.

Effectiveness of Various Sternal Closure Devices Post Adult Cardiac Surgery.

Background & Aim: Sternotomy remains a commonly used technique to access the heart for cardiac surgery worldwide. To date, there is no clear consensus on the single superior sternal closure technique. Patient-specific factors such as osteoporosis, diabetes, old age, body habitus influence a surgeon's choice in this matter as do techniques commonly used during the training period and used in the current workplace.

Congestion avoidance in 6G networks with V Gradient Geocast Routing Protocol.

This is a moment of heavy necessity for a dependable internet connection in the modern world, which is used to engage in business dealings, communicate with other people, entertain oneself, and lead a daily life. Therefore, a Wi-Fi 6 router must have an internal wire-free connection within a house or business. However, as they depend on the weather and are installed in ways that expose them to infiltration, they are vulnerable.

Variability in sustainability reporting - A multicountry study.

The urgent need for businesses worldwide to evolve is driven by environmental consciousness, social responsibility, and corporate governance. This study examines 678 sustainability reports across G20 countries and aims to provide global evidence on the determinants of sustainability reporting through content analysis. We calculate Sustainability Disclosure (SUSD) and Quality Index (QUID) for a select set of cross-sectional public companies.

Capillary-Enhanced Biomimetic Adhesion on Icy Surfaces for High-Performance Antislip Shoe-Soles.

The World Health Organization (WHO) reports 684,000 deaths/year due to slips and falls (SFs), with ∼38 million people requiring medical attention per annum. In particular, SFs on ice surfaces account for 45% of all SF incidents, costing over $100 billion globally in healthcare, intensive care, and insurance expenses. Current antislip solutions focus on hydrophobicity to repel interfacial fluids, aiming to maintain solid-to-solid contact.

Sarcomatous transformation of IDH-mutant astrocytoma matching to methylation class oligosarcoma following embolization, a case report.

The mesenchymal transformations of infiltrating gliomas are uncommon events. This is particularly true of IDH-mutant astrocytomas and oligodendrogliomas, in which mesenchymal transformation is exceedingly rare. oligosarcoma is a newly recognized methylation class (MC) that represents transformed 1p/19q co-deleted oligodendrogliomas, but recent studies indicate it may be non-specific.

Convergence of Nanotechnology and Machine Learning: The State of the Art, Challenges, and Perspectives.

Nanotechnology and machine learning (ML) are rapidly emerging fields with numerous real-world applications in medicine, materials science, computer engineering, and data processing. ML enhances nanotechnology by facilitating the processing of dataset in nanomaterial synthesis, characterization, and optimization of nanoscale properties. Conversely, nanotechnology improves the speed and efficiency of computing power, which is crucial for ML algorithms.

Association of IL1RN VNTR and NKG2A polymorphisms with hepatitis E infection, a case study from western India.

Interleukin 1 receptor antagonist (IL1RN) is a competitive inhibitor of interleukin 1 (IL-1). Natural killer cells (NK cells) contribute to the elimination of viruses by their antiviral effector function, which depends on a balance between inhibitory and activating receptor genes such as NKG2D and NKG2A. Using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assays, the association of intronic single-nucleotide polymorphisms (SNPs) in these genes with viral infection were assessed in 111 patients with hepatitis E virus (HEV) infection and 222 HEV-naive healthy controls.

Role of epidural disease in local control of spinal metastases treated with stereotactic body radiation therapy.

Spinal metastases can be contained in the bone or have epidural spread. Whether the extent of epidural involvement changes tumor response to therapy is unknown. The decision of when to treat disease progression with focal radiation therapy with or without surgery vs.

Humoral and cellular immune response to AZD1222 /Covishield and BV152/Covaxin COVID-19 vaccines among adults in India.

Several COVID-19 vaccines were developed using different approaches to prevent both symptomatic COVID-19 cases and fatalities. The adults were vaccinated with two doses of AZD1222/Covishield ( = 77) [manufactured by Serum Institute of India Pvt Ltd] vaccine and BV152/Covaxin ( = 99) [manufactured by Bharat Biotech] vaccine. They were assessed for immune response at pre-vaccination, 1 month post first and 6 months post second dose for anti-SARS-CoV-2 IgG antibody, surrogate neutralizing antibody (NAbs), immune phenotypes, antigen specific NK, B and T cell response, their effector functionality by ELISPOT and plasma cytokine profile.

Flag of convenience and the tragedy of the commons in maritime transportation.

Flag of convenience (FOC) refers to the practice of registering ships in foreign countries to benefit from lax regulations. While FOC offers several short-term cost advantages to ship owners and FOC countries, it poses significant threats to critical international interests, including environmental protection and marine habitat preservation. Despite global outrage and concerns over FOC's environmental impact, the number of FOC ships have continued to rise.

α-C(sp)-H (Hetero)Arylation of Thioethers Enabled by Photoexcited Triplet Ketone Catalysis.

We report herein α-C(sp)-H (hetero)arylation of thioethers enabled by dual nickel and photoexcited triplet ketone catalysis. The mild reaction conditions of this protocol tolerate a variety of functional groups and further facilitate the late-stage functionalization of biologically relevant molecules to afford corresponding products in moderate to good yields. Preliminary mechanistic studies suggest that the generation of the α-thioalkyl radical takes place through a hydrogen atom transfer (HAT) event, which is involved in the rate-limiting step and in the nickel cycle, the reaction of the α-thioalkyl radical with Ni(0)L catalyst followed by oxidative addition of aryl bromide is the dominating pathway.

Evaluation of functional transbilayer coupling in live cells by controlled lipid exchange and imaging fluorescence correlation spectroscopy.

Biophysical coupling between the inner and outer leaflets, known as inter-leaflet or transbilayer coupling, is a fundamental organizational principle in the plasma membranes of live mammalian cells. Lipid-based interactions between the two leaflets are proposed to be a primary mechanism underlying transbilayer coupling. However, there are only a few experimental evidence supporting the existence of such interactions in live cells.

Elevated Complement Activation Fragments and C1q-Binding Circulating Immune Complexes in Varied Phases of Chikungunya Virus Infection.

Chikungunya virus (CHIKV) is a causative agent of a disease continuum, ranging from an acute transient chikungunya fever to chronic incapacitating viral arthralgia. The interaction between anti-CHIKV antibodies and the complement system has recently received attention. However, the contribution of complement activation in CHIKV-induced pathologies has not been fully elucidated.

T-cell responses in COVID-19 survivors 6-8 months after infection: A longitudinal cohort study in Pune.

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune response is crucial for disease management, although diminishing immunity raises the possibility of reinfection.

Methods: We examined the immunological response to SARS-CoV-2 in a cohort of convalescent COVID-19 patients in matched samples collected at 1 and 6-8 months after infection. The peripheral blood mononuclear cells were isolated from enrolled study participants and flow cytometry analysis was done to assess the lymphocyte subsets of naive, effector, central memory, and effector memory CD4+ or CD8+ T cells in COVID-19 patients at 1 and 6-8 months after infection.

The HER2 flip-HER2 amplification of tumor cells in the cerebrospinal fluid of breast cancer patients with leptomeningeal disease: implications for treating the LM tumor with anti-HER2 therapy.

Introduction: CNSide is a platform that detects and characterizes tumor cells in the cerebrospinal fluid (CSF) of patients with leptomeningeal disease (LMD). The platform was validated per College of American Pathologists (CAP) and Clinical Laboratories Improvement Amendment (CLIA) guidelines and run as a commercial Laboratory Developed Test (LDT) at Biocept in San Diego, CA. The platform allows CSF tumor cell (CSF-TC) enumeration and biomarker characterization by fluorescent hybridization (FISH).

Automatic detection of potholes using VGG-16 pre-trained network and Convolutional Neural Network.

A self-driving car is necessary to implement traffic intelligence because it can vastly enhance both the safety of driving and the comfort of the driver by adjusting to the circumstances of the road ahead. Road hazards such as potholes can be a big challenge for autonomous vehicles, increasing the risk of crashes and vehicle damage. Real-time identification of road potholes is required to solve this issue.

Graphene and metal-organic framework hybrids for high-performance sensors for lung cancer biomarker detection supported by machine learning augmentation.

Conventional diagnostic methods for lung cancer, based on breath analysis using gas chromatography and mass spectrometry, have limitations for fast screening due to their limited availability, operational complexity, and high cost. As potential replacement, among several low-cost and portable methods, chemoresistive sensors for the detection of volatile organic compounds (VOCs) that represent biomarkers of lung cancer were explored as promising solutions, which unfortunately still face challenges. To address the key problems of these sensors, such as low sensitivity, high response time, and poor selectivity, this study presents the design of new chemoresistive sensors based on hybridised porous zeolitic imidazolate (ZIF-8) based metal-organic frameworks (MOFs) and laser-scribed graphene (LSG) structures, inspired by the architecture of the human lung.

Imperative connotation of SODs in cancer: Emerging targets and multifactorial role of action.

Superoxide dismutase (SOD) is a crucial enzyme responsible for the redox homeostasis inside the cell. As a part of the antioxidant defense system, it plays a pivotal role in the dismutation of the superoxide radicals ( ) generated mainly by the oxidative phosphorylation, which would otherwise bring out the redox dysregulation, leading to higher reactive oxygen species (ROS) generation and, ultimately, cell transformation, and malignancy. Several studies have shown the involvement of ROS in a wide range of human cancers.

Synergistic Merger of Ketone, Halogen Atom Transfer (XAT), and Nickel-Mediated C(sp)-C(sp) Cross-Electrophile Coupling Enabled by Light.

In the present manuscript, we have developed a unique catalytic system by merging photoexcited ketone catalysis, halogen atom transfer (XAT), and nickel catalysis to forge C(sp)-C(sp) cross-electrophile coupling products from unactivated iodoalkanes and (hetero)aryl bromides. The synergistic catalytic system works under mild reaction conditions and tolerates a variety of functional groups; moreover, this strategy allows the late-stage modification of medicinally relevant molecules. Preliminary mechanistic studies reveal the role of the α-aminoalkyl radical, which further participates in the XAT process with alkyl iodides to generate the desired alkyl radical, which eventually intercepts with the nickel catalytic cycle to liberate the products in good to excellent yields.

Hospital factors determining overall survival in cancer patients undergoing curative treatment.

Background: In oncology, overall survival (OS) and quality of life (QoL) are key indicators. The factors that affect OS and QoL include tumor-related characteristics (stage and grade), patient-related factors (performance status and comorbidities), and cancer-directed therapy (CDT)-related aspects. In addition, external factors such as governance or policy (e.