Storage-induced change in platelet transfusion response evaluated by serial transfusions from one donor to one patient.

Background: Storage of platelet concentrates (PCs) results in storage lesions with possible detrimental effects on platelet recovery after transfusion, which might affect their ability to prevent or arrest bleeding. The aim of this study was to compare the quality of PCs stored for 1 to 3 or 5 to 7 days by assessing the corrected count increment (CCI) after transfusion. To isolate the effects of storage time, we studied serial transfusions of PCs obtained from one donor and one donation, and transfused to one single recipient after storage for 1 to 3 days and 5 to 7 days.

In vitro function of platelets treated with ultraviolet C light for pathogen inactivation: a comparative study with nonirradiated and gamma-irradiated platelets.

Background: During storage of platelet concentrates (PCs) replication of contaminating pathogens might occur, which can be prevented by various pathogen inactivation (PI) methods using photoactive substances in combination with ultraviolet (UV) light. A new method uses only UVC light for PI without photoactive substances. This study evaluates the in vitro function, including hemostatic properties (clot formation and elasticity), of platelets (PLTs) treated with UVC light.

In vitro properties of platelets stored in a small container for pediatric transfusion.

Background: The quality of a platelet (PLT) concentrate (PC) is affected by the number of PLTs in relation to the size and gas permeability of the container. This study evaluates the in vitro function, including hemostatic properties (clot formation and elasticity), of PLTs stored in a container of standard or small size.

Study Design And Methods: PCs with 30% plasma and 70% PLT additive solution were prepared from buffy coats.

In vitro properties of platelets stored in three different additive solutions.

Background: New platelet (PLT) additive solutions (PASs) contain compounds that might improve the storage conditions for PLTs. This study compares the in vitro function, including hemostatic properties (clot formation and elasticity), of PLTs in T-Sol, Composol, or SSP+ during storage for 5 days.

Study Design And Methods: Fifteen buffy coats were pooled and divided into three parts.

In vitro quality of platelets during prolonged storage after washing with three platelet additive solutions.

Background And Objectives:   Patients with anaphylactic transfusion reactions require washed platelet concentrates (PCs) for subsequent platelet (PLT) transfusions. New PLT additive solutions (PASs) contain substances that might be beneficial for the preservation of PLT function during storage. This study compares the quality of PLTs washed and stored with T-Sol, Composol or SSP+.

Autologous platelets have no effect on the healing of human achilles tendon ruptures: a randomized single-blind study.

Background: Animal studies have shown that local application of platelet-rich plasma (PRP) stimulates tendon repair. Preliminary results from a retrospective case series have shown faster return to sports.

Hypothesis: Autologous PRP stimulates healing of acute Achilles tendon ruptures.

Platelet quality after washing: the effect of storage time before washing.

Background: Patients who have experienced anaphylactic transfusion reactions receive washed platelet (PLT) concentrates (PCs) where the plasma has been substituted with a PLT additive solution. This study compares the in vitro quality of PCs washed at the beginning of the storage period (Day 1) to PCs washed at the end of storage (Day 7).

Study Design And Methods: PLTs were prepared by the buffy coat procedure.

The effect of gamma irradiation on the quality of apheresis platelets during storage for 7 days.

Background: This study compares the quality of gamma-irradiated versus nonirradiated platelet (PLT) concentrates (PCs) during storage for 7 days as assessed by various in vitro methods. A new technique, free oscillation rheometry (FOR), which measures clotting time and coagulum elasticity, was also used to evaluate the PLT function.

Study Design And Methods: Single-donor PLTs were collected by apheresis technique (n = 20).

The quality of platelet concentrates produced by COBE Spectra and Trima Accel cell separators during storage for 7 days as assessed by in vitro methods.

Background: The quality of platelet (PLT) concentrates (PCs) can be evaluated with various in vitro methods. A new technique, free oscillation rheometry (FOR), can be used to monitor coagulation properties of PCs and gives information on clotting time and coagulum elasticity. This study compared the quality of apheresis PCs produced by the COBE Spectra and Trima Accel cell separators (both Gambro BCT) during storage for 7 days with in vitro tests including FOR.