Publications by authors named "Trinidad Dierssen-Sotos"
Objective: This study examines the impact of the COVID-19 pandemic on both routine and non-routine vaccinations in infants during their initial 18 months of life, concurrently exploring the complex influence of sociodemographic factors.
Methods: A cohort study was conducted, involving 2007 children in two distinct periods: pre-pandemic (January-June 2018) and pandemic (March 2020-May 2021). Participants were classified into two cohorts: 962 children in the 2018 group and 1045 children in the 2020-21 group.
Background: Prostate cancer (PC) is the second most frequent tumor in men worldwide; however, its etiology remains largely unknown, with the exception of age and family history. The wide variability in incidence/mortality across countries suggests a certain role for environmental exposures that has not yet been clarified.
Objective: To evaluate the association between risk of PC (by clinical profile) and residential proximity to pollutant industrial installations (by industrial groups, groups of carcinogens, and specific pollutants released), within the context of a Spanish population-based multicase-control study of incident cancer (MCC-Spain).
Comments on "Otolaryngological manifestations in monkeypox".
Acta Otorrinolaringol Esp (Engl Ed)
April 2024
Characteristics of patients who died in the hospital emergency service during the SARS-CoV-2 pandemic: a retrospective cohort study in a tertiary hospital in Spain.
Intern Emerg Med
June 2024
Article Synopsis
- This study examines the characteristics of patients who died in the Hospital Emergency Department of a Spanish hospital, focusing on those who died from SARS-CoV-2 during the COVID-19 pandemic.
- A retrospective analysis was conducted on patients over 18 who died from June 2019 to December 2020, revealing a 42% increase in deaths during the first wave of COVID-19.
- The study found that patients who died from SARS-CoV-2 were generally younger during the first wave (average age 78.6 years) compared to the second wave (average age 91.8 years), with no significant differences in gender or comorbidities.
Background: Since 1978 many children are born thanks to assisted reproductive technology (ART). However, the long-term effects of these therapies are still not fully known. Our objective is to evaluate the risk of cerebral palsy (CP) after ART compared with that in those spontaneously conceived (SC) and to examine this risk in single, multiple, and preterm births and the evolution of the risk over the years.
View Article and Find Full Text PDFBackground: Some researchers have suggested that zinc (Zn) could reduce the risk of prostate cancer (PC). However, research from observational studies on the relationship between PC risk and biomarkers of Zn exposure shows conflicting results.
Objectives: To evaluate the association between toenail Zn and PC, considering tumour extension and aggressiveness, along with a gene-environment approach, exploring the interaction of individual genetic susceptibility to PC in the relationship between toenail Zn and PC.
Article Synopsis
- The study investigates the impact of cigarette smoking on breast cancer risk, highlighting the conflicting effects it may have due to its carcinogenic and antiestrogenic properties.
- Analysis from a large population-based study involving 1733 breast cancer cases and 1903 controls revealed that smoking increases the risk of premenopausal breast cancer, especially in long-term smokers (≥30 years).
- Conversely, for postmenopausal women, smoking may lower the risk of breast cancer, particularly in those who have stopped smoking for at least 10 years, indicating that menopausal status significantly influences the relationship between smoking and breast cancer risk.
Article Synopsis
- A recent study analyzed genetic data from over 156,000 prostate cancer cases and 788,000 controls from diverse populations, significantly increasing the representation of non-European participants.
- Researchers identified 187 new genetic risk variants for prostate cancer, bringing the total to 451, enhancing understanding of genetic factors across different ancestries.
- The developed genetic risk score (GRS) showed varying risk levels for prostate cancer among different ancestry groups, highlighting its potential for better risk assessment, especially in men of African descent.
Purpose: To build models combining circulating microRNAs (miRNAs) able to identify women with breast cancer as well as different types of breast cancer, when comparing with controls without breast cancer.
Method: miRNAs analysis was performed in two phases: screening phase, with a total n = 40 (10 controls and 30 BC cases) analyzed by Next Generation Sequencing, and validation phase, which included 131 controls and 269 cases. For this second phase, the miRNAs were selected combining the screening phase results and a revision of the literature.
Introduction: Several indicators were employed to manage the COVID-19 pandemic. In this study, our objective was to compare the instantaneous reproductive number and the epidemic growth rate in the Spanish population.
Methods: Data on daily numbers of cases, admissions into hospitals, admissions into ICUs, and deaths due to COVID-19 in Spain from March 2020 to March 2022 were obtained.
Article Synopsis
- The study investigated the link between artificial sweeteners (AS) like aspartame and certain cancers, using a population sample from the MCC-Spain study, which included various cancer cases and controls.
- Overall, the research found no significant association between AS consumption and cancer risk; however, some links were observed specifically for participants with diabetes.
- High consumption of aspartame was correlated with an increased risk of stomach cancer, while a lower risk was noted for breast cancer in the same group, highlighting the need for cautious interpretation due to small sample sizes for certain cancers.
This study will describe trends in the use of emergency departments before and after the Spanish State of Alarm, especially in pathologies not directly related to this infection. A cross-sectional study was conducted of all visits to the emergency departments in two third-level hospitals in two Spanish communities during the Spanish State of Alarm, compared with the same period of the previous year. The variables collected included the day of the week, the time of the visit, the duration of the visit, the final destination of the patients (home, admission to a conventional hospitalization ward, admission to the intensive care unit, and death), and the diagnosis at discharge according to the International Classification of Diseases 10th Revision.
View Article and Find Full Text PDFArticle Synopsis
- * A study investigated whether 41 of these genetic variants could predict overall survival (OS) and time to first treatment (TTFT) in 1,039 CLL patients but found only weak associations that lacked significance after adjusting for multiple tests.
- * The findings indicated that genetic risk variants do not significantly affect survival or disease progression in CLL patients, with polygenic risk scores providing only modest predictive ability for patient outcomes.
Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC).
Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project.
Article Synopsis
- - The COVID-19 pandemic has disrupted pregnancy management and work conditions, but little research has been done on how these changes impact pregnant women leaving work earlier and the effects on pregnancy outcomes
- - A study in Cantabria, Spain, analyzed 760 women who were pregnant during 2020, looking specifically at factors that influenced whether they left work before the 26th week of pregnancy
- - Findings revealed that factors like having a university degree, working in-person, being born outside Europe, and not smoking were linked to a lower likelihood of leaving work early, but leaving work earlier did not correlate with different pregnancy outcomes.
Article Synopsis
- Breast and prostate cancers have been linked to circadian disruption, but previous research on sleep duration's impact on cancer risk has shown inconsistent results.
- This study, part of the MCC-Spain project, analyzed a large population of breast (1738 cases) and prostate cancer (1112 cases) patients alongside matched controls, focusing on various sleep characteristics like duration, quality, and napping habits.
- The findings indicated no strong associations between sleep patterns and cancer risk, but a notable positive relationship was found between breast cancer risk and taking habitual siestas, especially when frequency or duration increased, alongside correlations between recent sleep problems and both cancer types.
Objective: To extend knowledge about the long-term use of hormones in hormone therapy or oral contraception as prognostic factors in breast cancer.
Methods: The MCC-Spain project is a cohort of 1,685 women with incident breast cancer recruited in Spain. Recruitment was carried out between 2007 and 2010, and the follow-up finished in December 2017.
Evolution of Medical Students' Perception of the Patient's Right to Privacy.
Int J Environ Res Public Health
September 2022
Article Synopsis
- - This study analyzes medical students' views on patient privacy during clinical rotations, focusing on how various factors like age, sex, and parents' education relate to these perceptions.
- - A survey of 129 Spanish medical students revealed that only 31% had signed confidentiality agreements, and many reported infrequent introductions by doctors in patient rooms.
- - Nearly 50% of students admitted they would photograph a patient's report without consent, highlighting a concerning lack of understanding about privacy rights among them, especially among younger students and those with less educated parents.
End-of-life care and the limitation of therapeutic effort are among the most controversial aspects of medical practice. Many subjective factors can influence decision-making regarding these issues. The Q methodology provides a scientific basis for the systematic study of subjectivity by identifying different thought patterns.
View Article and Find Full Text PDFDietary inflammatory index and prostate cancer risk: MCC-Spain study.
Prostate Cancer Prostatic Dis
September 2022
Background: The etiology of prostate cancer (PCa) is not well-known, and the role of diet is not well established. We aimed to evaluate the role of the inflammatory power of the diet, measured by the Dietary Inflammatory Index (DII), on the risk of PCa.
Methodology: A population-based multicase-control (MCC-Spain) study was conducted.
Background: Cadmium is a ubiquitous and persistent metal, associated with different harmful health effects and with increased morbidity and mortality. Understanding the main sources of exposure is essential to identify at risk populations and to design public health interventions.
Objective: To evaluate cadmium exposure in a random-sample of general adult population from three regions of Spain, assessed by the urinary cadmium (U-Cd) concentration, and to identify its potential determinants and sex-specific differences, including sociodemographic, lifestyle and dietary factors.
The aim was to assess the effect of adherence to the Mediterranean Diet, measured with five different indexes, on the risk of gastric cancer. Data come from the multicase-control study MCC-Spain, which included 354 gastric cancer cases and 3040 controls with data on diet. We used five indexes to evaluate adherence to the Mediterranean diet and assess the association between each pattern with the risk of gastric cancer, using multivariate logistic regression.
View Article and Find Full Text PDFPregnancy and Birth Outcomes during the Early Months of the COVID-19 Pandemic: The MOACC-19 Cohort.
Int J Environ Res Public Health
October 2021
The new coronavirus, SARS-CoV-2, is devastating for specific groups of patients, but currently there is not enough information concerning its effects on pregnant women. The purpose of this study is to identify the impact of SARS-CoV-2 infection on pregnancy and the consequences that it could cause. We studied a cohort of pregnant ladies who were tested for SARS-CoV-2 infection by RT-PCR and classified as infected or not infected.
View Article and Find Full Text PDFBackground: Breastfeeding is associated with lower incidence and severity of lower respiratory tract disease. However, little is known about the relationship between feeding type and breastfeeding duration with bronchiolitis in a child's first year.
Methods: A prospective cohort study of 969 newborn babies were followed-up for 12 months to determine breastfeeding duration, feeding type, feeding trajectory, and bronchiolitis episodes at Marqués de Valdecilla University Hospital, Spain in 2018.
Article Synopsis
- The study looked at how having family members with colorectal cancer (CRC) affects a person's risk of getting CRC themselves.
- They found that if someone has a first-degree relative (like a parent or sibling) who had CRC, their risk doubles.
- The risk is even higher if the family member was diagnosed before age 50, so these people should take extra steps to prevent CRC.