Publications by authors named "Trinh Thu Huong"
High prevalence of maternal mosaic monosomy X in pregnant women in Vietnam.
J Matern Fetal Neonatal Med
December 2023
Article Synopsis
- The study aimed to assess the prevalence of maternal mosaic monosomy X (MMXO) among pregnant women in Vietnam using noninvasive prenatal screening methods.
- Out of over 105,000 women analyzed, 295 were suspected of having MMXO, with further testing confirming 125 cases, resulting in a confirmed prevalence of 0.118%.
- The results indicate that MMXO significantly affects chromosome X measurements, leading to many false positives when using size-based methods, while the count-based method is better for accurate results.
Genetic landscape of recessive diseases in the Vietnamese population from large-scale clinical exome sequencing.
Hum Mutat
October 2021
Article Synopsis
- Accurate profiling of recessive diseases in the Vietnamese population is crucial for developing effective carrier screening programs, but minorities are often underrepresented in genetic research.
- A comprehensive study analyzed genetic data from 985 Vietnamese individuals, identifying 118 recessive diseases and 164 variants, with some diseases having significantly higher carrier frequencies compared to global populations.
- The research revealed three prevalent diseases—beta-thalassemia, citrin deficiency, and phenylketonuria—with notable carrier rates, and introduced seven novel pathogenic variants, enhancing the understanding of recessive disorders specific to Vietnamese individuals.
Article Synopsis
- * This study analyzed NIPT data from 2,683 pregnant Vietnamese women, identifying over 8 million genetic variants, with 8.2% being unique to this population.
- * The findings revealed 24,487 disease-related genetic variants and significant differences in allele frequency compared to other populations, underscoring the necessity for studies focused on the Vietnamese community.
Cervical cancer is preventable but continues to cause the deaths of more than 270,000 women worldwide each year, most of them in developing countries where programs to detect and treat precancerous lesions are not affordable or available. Studies have demonstrated that screening by visual inspection of the cervix using acetic acid (VIA) is a simple, affordable, and sensitive test that can identify precancerous changes of the cervix so that treatment such as cryotherapy can be provided. Government partners implemented screening and treatment using VIA and cryotherapy at demonstration sites in Peru, Uganda, and Vietnam.
View Article and Find Full Text PDFCervical cancer is preventable but continues to cause the deaths of more than 270,000 women worldwide each year, most of them in developing countries where programs to detect and treat precancerous lesions are not affordable or available. Studies have demonstrated that screening by visual inspection of the cervix using acetic acid (VIA) is a simple, affordable, and sensitive test that can identify precancerous changes of the cervix so that treatment such as cryotherapy can be provided. Government partners implemented screening and treatment using VIA and cryotherapy at demonstration sites in Peru, Uganda, and Vietnam.
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