Comparative analysis of the postadmission and antemortem oropharyngeal and rectal swab microbiota of ICU patients.

Shotgun metabarcoding was conducted to examine the microbiota in a total of 48 samples from 12 critically ill patients, analyzing samples from both the oropharynx and rectum. We aimed to compare their postadmission microbiota, characterized as moderately dysbiotic, with the severely dysbiotic antemortem microbiota associated with patients' deaths. We found that, compared with postadmission samples, patient antemortem swab samples presented moderate but not significantly decreased diversity indices.

A study on the antioxidant, anti-inflammatory, and xanthine oxidase inhibitory activity of the Artemisia vulgaris L. extract and its fractions.

Ethnopharmacological Relevance: Vietnamese people use mugwort (Artemisia vulgaris L.) to treat arthritis and gout. Our previous research shows that mugwort contains flavonoids, and its extract possesses antibacterial and anti-inflammatory activities.

Integrative multi-region molecular profiling of primary prostate cancer in men with synchronous lymph node metastasis.

Localized prostate cancer is frequently composed of multiple spatially distinct tumors with significant inter- and intra-tumoral molecular heterogeneity. This genomic diversity gives rise to many competing clones that may drive the biological trajectory of the disease. Previous large-scale sequencing efforts have focused on the evolutionary process in metastatic prostate cancer, revealing a potential clonal progression to castration resistance.

Endothelial knockdown of the tumor suppressor, , increases inflammation in ventilator-induced lung injury.

Chronic cigarette smoke exposure decreases lung expression of which is known to protect the endothelial barrier during infectious models of acute respiratory distress syndrome (ARDS). Proteomic analysis of -silenced endothelial cells (ECs) was done using tandem mass tag mass spectrometry (TMT-MS). -silenced ECs as well as those isolated from endothelial cell knockout (EC KO) mice were subjected to cyclic stretch (18% elongation, 0.

Long-term safety and immunologic outcomes of daily oral immunotherapy for peanut allergy.

Background: Oral immunotherapy containing peanut () allergen powder-dnfp (PTAH) (Palforzia [Aimmune Therapeutics, Brisbane, Calif]) for 9 to 12 months resulted in higher tolerated amounts of peanut protein in PTAH-treated individuals aged 4 to 17 years with peanut allergy than in placebo-treated participants.

Objective: We aimed to describe additional long-term pooled safety data and changes in peanut sensitization markers from baseline through approximately 5 years of treatment.

Methods: The results from 6 clinical trials of PTAH (3 controlled and 3 open-label extension studies [N = 1227]) were pooled, and analysis of safety outcomes and immunologic data was performed.

Green, facile and fast synthesis of silver nanoparticles by using solution plasma techniques and their antibacterial and anticancer activities.

We herein present a simple, fast, efficient and environmentally friendly method for preparing silver nanoparticles (AgNPs) using the solution plasma method in the presence of extracts from (). The effects of extract concentrations and the applied voltage on the formation of AgNPs were investigated. Surface plasmon resonance spectra show a strong peak at 413 nm for the prepared samples.

A molybdenum disulfide/nickel ferrite-modified voltammetric sensing platform for ultra-sensitive determination of clenbuterol under the presence of an external magnetic field.

The electrochemical behavior and sensing performance of an electrode modified with NiFeO (NFO), MoS, and MoS-NFO were thoroughly investigated using CV, EIS, DPV, and CA measurements, respectively. MoS-NFO/SPE provided a higher sensing performance towards the detection of clenbuterol (CLB) than other proposed electrodes. After optimization of pH and accumulation time, the current response recorded at MoS-NFO/SPE linearly increased with an increase of CLB concentration in the range from 1 to 50 μM, corresponding to a LOD of 0.

Overlapping Features of Primary Cutaneous Marginal Zone Lymphoproliferative Disorder and Primary Cutaneous CD4 + Small/Medium T-Cell Lymphoproliferative Disorder : A Diagnostic Challenge Examined by Genomic Analysis.

Primary cutaneous marginal zone lymphoproliferative disorder (PCMZL) and primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder (CD4 + TLPD) are indolent lymphoproliferative disorders. However, cases with overlapping features can be challenging. We identified 56 CD4 + TLPD and 38 PCMZL cases from our pathology archives.

Improving the efficiency of n-Si/PEDOT:PSS hybrid solar cells by incorporating AuNP-decorated graphene oxide as a nanoadditive for conductive polymers.

A gold nanoparticle-decorated graphene oxide (GO-AuNP) hybrid material was prepared by using the chemical reduction method. The obtained results showed that the AuNPs of about of 15 nm are well bound on the surface of GO. The GO-AuNP hybrid material was used for transparent conductive film (TCF) and organic/inorganic hybrid solar cells.

Use of a Cardiopulmonary Resuscitation Video to Assist Intensive Care Unit Resident Physicians during Code Status Discussions.

Background: Code status discussions (CSDs) in the intensive care unit (ICU) are frequently conducted by resident physicians. Cardiopulmonary resuscitation (CPR) videos when used to aid ICU patients and families in code status decision making have been shown to have a positive impact. The purpose of this study is to evaluate the impact of a CPR video, when made available to supplement trainee-patient CSDs, on ICU residents' comfort level when conducting these discussions.

Comparative effects of crystalline, poorly crystalline and freshly formed iron oxides on the colloidal properties of polystyrene microplastics.

Colloid-sized microplastics (MPs) are ubiquitous in aquatic environments and can share the same transport route together with various crystalline, poorly crystalline and freshly formed iron oxides. However, the colloidal interactions between these colloid constituents are not fully understood. This study was designed to investigate the colloidal properties of polystyrene microplastics (PSMPs) under the influence of haematite, goethite, ferrihydrite and freshly formed Fe oxide (FFFO).

Enhanced power conversion efficiency of an n-Si/PEDOT:PSS hybrid solar cell using nanostructured silicon and gold nanoparticles.

Herein, the effect of nanostructured silicon and gold nanoparticles (AuNPs) on the power conversion efficiency (PCE) of an n-type silicon/poly(3,4-ethylene dioxythiophene):poly(styrene sulfonate) (n-Si/PEDOT:PSS) hybrid solar cell was investigated. The Si surface modified with different nanostructures including Si nanopyramids (SiNPs), Si nanoholes (SiNHs) and Si nanowires (SiNWs) was utilized to improve light trapping and photo-carrier collection. The highest power conversion efficiency (PCE) of 8.

Molecular Characterization of Clear Cell Renal Cell Carcinoma Reveals Prognostic Significance of Epithelial-mesenchymal Transition Gene Expression Signature.

Background: There is an ongoing need to develop prognostic biomarkers to improve the management of clear cell renal cell carcinoma (ccRCC).

Objective: To leverage enriched pathways in ccRCC to improve risk-stratification.

Design, Setting, And Participants: We retrospectively identified two complementary discovery cohorts of patients with ccRCC who underwent (1) radical nephrectomy (RNx) with inferior vena cava tumor thrombectomy (patients = 5, samples = 24) and (2) RNx for localized disease and developed recurrence versus no recurrence (n = 36).

Development of a Whole-urine, Multiplexed, Next-generation RNA-sequencing Assay for Early Detection of Aggressive Prostate Cancer.

Background: Despite biomarker development advances, early detection of aggressive prostate cancer (PCa) remains challenging. We previously developed a clinical-grade urine test (Michigan Prostate Score [MiPS]) for individualized aggressive PCa risk prediction. MiPS combines serum prostate-specific antigen (PSA), the TMPRSS2:ERG (T2:ERG) gene fusion, and PCA3 lncRNA in whole urine after digital rectal examination (DRE).

Electrochemical Sensor Based on Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral FeO/Chitosan Composite for Glyphosate Detection.

In this work, reduced graphene oxide/double-walled carbon nanotubes/octahedral-FeO/chitosan composite material modified screen-printed gold electrodes (rGO/DWCNTs/Oct-FeO/Cs/SPAuE) under inhibition of urease enzyme was developed for the determination of glyphosate (GLY). The electrochemical behaviors of GLY on these electrodes were evaluated by square wave voltammetry (SWV). With the electroactive surface area is 1.

Facile synthesis of graphene oxide from graphite rods of recycled batteries by solution plasma exfoliation for removing Pb from water.

We herein present a simple, fast, efficient and environmentally friendly technique to prepare graphene oxide (GO) from graphite rods of recycled batteries by using solution plasma exfoliated techniques at atmospheric pressure. The prepared GO with an average 3 nm-thickness and 1.5 μm-length, having large surface area and high porosity, has been used to remove Pb(ii) ions from the water.

Solar Cell Based on Hybrid Structural SiNW/Poly(3,4 ethylenedioxythiophene): Poly(styrenesulfonate)/Graphene.

Solar energy is considered as a potential alternative energy source. The solar cell is classified into three main types: i) solar cells based on bulk silicon materials (monocrystalline, polycrystalline), ii) thin-film solar cells (CIGS, CdTe, DSSC, etc.), and iii) solar cells based on nanostructures and nanomaterials.

The intertemporal evolution of agriculture and labor over a rapid structural transformation: Lessons from Vietnam.

We combine nationally representative household and labor force survey data from 1992 to 2016 to provide a detailed description of rural labor market evolution and how it relates to the structural transformation of rural Vietnam, especially within the agricultural sector. Our study adds to the emerging literature on structural transformation in low-income countries using micro-level data and helps to answer several policy-related questions. We find limited employment creation potential of agriculture, especially for youth.

Enhanced mechanical and wear properties of Al6061 alloy nanocomposite reinforced by CNT-template-grown core-shell CNT/SiC nanotubes.

Novel one-dimensional template-grown coaxial SiC@carbon nanotubes (SiC@CNTs) were fabricated using a chemical vapor deposition method. To facilitate the formation of SiC on CNT template, a molecular-level mixing process was used to coat the surface of commercial multiwalled carbon nanotubes (MWCNTs) by FeO. These Fe-CNTs were transformed into SiC@CNT nanotubes, which were then mixed with Al6061 alloy and consolidated by spark plasma sintering to obtain Al6061-SiC@CNT nanocomposites.

Carbon Nanomaterial-Based Nanofluids for Direct Thermal Solar Absorption.

Recently, many scientists have been making remarkable efforts to enhance the efficiency of direct solar thermal absorption collectors that depends on working fluids. There are a number of heat transfer fluids being investigated and developed. Among these fluids, carbon nanomaterial-based nanofluids have become the candidates with the most potential by the heat absorbing and transfer properties of the carbon nanomaterials.

A novel electrochemical sensor based on double-walled carbon nanotubes and graphene hybrid thin film for arsenic(V) detection.

In this work, we demonstrate the preparation of hybrid thin films based on double-walled carbon nanotubes and graphene for electrochemical sensing applications. The hybrid films were synthesized on polycrystalline copper foil by thermal chemical vapor deposition under low pressure. This carbonaceous hybrid film has exhibited high transparency with a transmittance of 94.