Publications by authors named "Trinh M Pham"
Localized prostate cancer is frequently composed of multiple spatially distinct tumors with significant inter- and intra-tumoral molecular heterogeneity. This genomic diversity gives rise to many competing clones that may drive the biological trajectory of the disease. Previous large-scale sequencing efforts have focused on the evolutionary process in metastatic prostate cancer, revealing a potential clonal progression to castration resistance.
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- * Current methods for detecting CTCs in blood samples are not sensitive or specific enough to fully exploit their potential for disease diagnosis and monitoring.
- * This study presents a novel method using functionalized graphene oxide nanosheets on a gold surface to effectively isolate CTCs from the blood of cancer patients, achieving high sensitivity even at low cell concentrations.