A prospective longitudinal study to evaluate bone health, implication of FRAX tool and impact on quality of life (FACT-P) in advanced prostate cancer patients.

Background: Androgen-deprivation therapy (ADT) as a treatment modality in advanced prostate cancer has deleterious effect on bone mineral density (BMD) and quality of life (QOL). Using FRAX (Fracture Risk Assessment) model, candidates at high risk of fractures can be predicted and appropriate treatment can be initiated at early step to prevent skeletal-related events. Objectives of the present study were to evaluate bone health, implication of FRAX tool in advanced prostate cancer and to see the impact of ADT and Bone-directed therapy (BDT) on FRAX and FACT-P QOL scores.

Foreign body (kidney beans) in urinary bladder: An unusual case report.

Introduction: Foreign body in urinary bladder has always been a topic of interest amongst the urologists and surgeon. Foreign body in lower urinary tract is not an unusual finding. Different types of foreign bodies has been retrieved from the lower urinary tract like for example, electric wire, safety pin, hairclip, intrauterine contraceptive device (IUCD), gauze pieces, battery, leech, hairballs and so on.

Electron microscopic changes of detrusor in benign enlargement of prostate and its clinical correlation.

Aims: To study the ultra structural changes in bladder musculature in cases of BPE and their clinical relevance.

Material And Methods: In this descriptive longitudinal, controlled, observational study patients were enrolled into three groups, group 1, group 2A and group 2B. Control group (group-1) consisted of age matched normal male patients, who underwent surveillance or diagnostic cystoscopy for microscopic hematuria or irritative symptoms.

Heat shock protein 70-2 (HSP70-2) overexpression in breast cancer.

Background: Breast cancer is one of the leading cause of cancer-related deaths in women worldwide and increasing rapidly in developing countries. In the present study, we investigated the potential role and association of HSP70-2 with breast cancer.

Methods: HSP70-2 expression was examined in 154 tumor and 103 adjacent non-cancerous tissue (ANCT) specimens and breast cancer cell lines (MCF7, BT-474, SK-BR-3 and MDA-MB-231) by RT-PCR, quantitative-PCR, immunohistochemistry, Western blotting, flow cytometry and indirect immunofluorescence.

Heat shock protein 70-2 (HSP70-2) is a novel therapeutic target for colorectal cancer and is associated with tumor growth.

Background: Colorectal cancer (CRC) is the third leading cause of cancer related deaths worldwide both in men and women. Our recent studies have indicated an association of heat shock protein 70-2 (HSP70-2) with bladder urothelial carcinoma. In the present study, we investigated the association of HSP70-2 with various malignant properties of colorectal cancer cells and clinic-pathological features of CRC in clinical specimens.

Primary neuroectodermal tumor of penis (PNET)--a case report.

Primary neuroectodermal tumor (PNET) is a rare entity with high malignant potential. It usually affects the skeletal system and primary extraskeletal involvement is uncommon. Because of rarity of tumor in the penis, only a few cases have been reported.