Pseudohalide Ions as Ligands to Tune Architecture and Luminescence of Polymetallic CU(I) Assemblies.

The reaction of preassembled Cu(I) bimetallic units {Cu(dppm)} and {Cu(dppa)} (dppm: bis(diphenylphosphino)methane and dppa: bis(diphenylphosphino)amine) with pseudohalide linkers (azido, dicyanamide, and tricyanomethanide) allows for the quantitative and selective preparation of three discrete tetrametallic metallacycles of formula [Cu(μ-dppm)(N)](PF), [Cu(μ-dppm)(N(CN))](PF), and [Cu(μ-dppm)(C(CN))]. To explore further the impact of the linker on the architecture and dimensionality of the molecular edifice, the study was extended to more sophisticated tetradentate cyanocarbanion ligands (tcnsMe: 2-(methylthio)-1,1,3,3-propanetetracarbonitrile and tcnsEt: 2-(ethylthio)-1,1,3,3-propanetetracarbonitrile). Three ladder-like one-dimensional coordination polymers and an octametallic metallacycle have been obtained.

Circulation patterns and molecular epidemiology of human respiratory syncytial virus over five consecutive seasons in Morocco.

Background: Respiratory syncytial virus (HRSV) is the leading cause of respiratory tract infections in infants and young children. we investigated the prevalence and characteristics of HRSV in Morocco and explored trends in circulating genotypes through partial G gene analysis of HRSV strains prevalent from 2012 to 2017.

Methods: Respiratory samples were gathered from both outpatients and inpatients meeting ILI or SARI case definitions.

Factors associated with hospitalization for seasonal influenza in Morocco.

Background: Morocco is actively working towards expanding its influenza vaccine policy to cover high-risk groups, as recommended by the World Health Organization (WHO).

Aims: We assessed the risk factors for influenza-associated hospitalization for severe acute respiratory infections (SARI) that occurred during the last 5 seasons.

Methods: We conducted a retrospective, analytical study among patients recruited in the ambulatory and hospital sites of the influenza sentinel surveillance system in Morocco between 2014 and 2019.

Influenza-associated severe acute respiratory infections among children under five years old in Morocco, September 2017 to March 2019.

The main aim of this research is to investigate the trend of influenza infection among children under 5 years with severe acute respiratory infections (SARI) as well as those who suffer from a high burden of disease. This research is based on a survey conducted from September 2017 to March 2019. During this period nasopharyngeal swabs were collected in a group of 942 children under 5 years with SARI, admitted in pediatric services of 8 sentinel hospitals.

Design and Rationale of the National Observational Multicentric Tunisian Registry of Hypertension: Protocol for Evaluating Hypertensive Patient Care in Clinical Practice.

Background: This study was designed to evaluate the care of hypertensive patients in daily clinical practice in public and private centers in all Tunisian regions.

Objective: This study will provide us an overview of hypertension (HTN) management in Tunisia and the degree of adherence of practitioners to international recommendations.

Methods: This is a national observational cross-sectional multicenter study that will include patients older than 18 years with HTN for a duration of 4 weeks, managed in the public sector from primary and secondary care centers as well as patients managed in the private sector.

Viral aetiology of influenza-like illnesses and severe acute respiratory illnesses in Morocco, September 2014 to December 2016.

Background: There is a scarcity of information on the viral aetiology of influenza-like illness (ILI) and severe acute respiratory infection (SARI) among patients in Morocco.

Methods: From September 2014 to December 2016, we prospectively enrolled inpatients and outpatients from all age groups meeting the World Health Organization (WHO) case definition for ILI and SARI from 59 sentinel sites. The specimens were tested using real-time monoplex reverse-transcription polymerase chain reaction method for detecting 16 relevant respiratory viruses.

Anterolateral Papillary Muscle Rupture Revealing Infective Endocarditis.

The rupture of mitral papillary muscles is a very rare complication of infective endocarditis (IE). We report a case of anterolateral papillary muscle rupture resulting in severe mitral regurgitation due to IE in a young man without previous heart disease. The patient underwent urgent mitral valve replacement.

Epidemiologic features and management of hypertension in Tunisia, the results from the Hypertension National Registry (NaTuRe HTN).

Background: Hypertension is the leading cause of morbi-mortality in our country. Thus, we conducted this national survey on hypertension to analyze the profile of the Tunisian hypertensive patient and to assess the level of blood pressure control.

Methods: Nature HTN is an observational multicentric survey, including hypertensive individuals and consulting their doctors during the period of the study.

[Impact of socioeconomic factors on blood pressure control: Observational study about 2887 hypertensive patients].

Introduction: Despite therapeutic progress, less than half of hypertensive patients are controlled. The objective of this study was to examine the links between blood pressure control and socioeconomic factors.

Methods: We used data collected in the cardiology department of Sfax University Hospital as part of the Tunisian national hypertension registry.

Spin Crossover and High-Spin State in Fe(II) Anionic Polymorphs Based on Tripodal Ligands.

Two new mononuclear Fe(II) polymorphs, [(CH)N][Fe(pyC-OEt)(NCS)] () and [(CH)N][Fe(pyC-OEt)(NCS)] () (pyC-OEt = tris(pyridin-2-yl)ethoxymethane), have been synthesized and characterized by single-crystal X-ray diffraction, by magnetic and photomagnetic measurements, and by detailed variable-temperature infrared spectroscopy. The molecular structure, in both complexes, is composed of the same anionic [Fe(pyC-OEt)(NCS)] complex (two units for and one unit for ) generated by coordination to the Fe(II) metal center of one tridentate pyC-OEt tripodal ligand and three terminal κ-SCN coligands. Magnetic studies revealed that polymorph displays a high-spin (HS) state over the entire studied temperature range (300-10 K), while complex exhibits an abrupt and complete spin crossover (SCO) transition at ca.

An unusual cause of a complete heart block in a young healthy man! (a case report).

Acute myocarditis represents a challenging diagnosis as there is no pathognomonic clinical presentation. It is rare to see heart block as the first-and-only presentation of infectious myocarditis. We report the case of a young healthy patient who presented with syncope secondary to a complete heart block.

Three COVID-19 cases with a long-term viral shedding period in Tunisia.

Novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has become a public health emergency of international concern. This was first emerged in Wuhan, Hubei Province, China, and then has become widespread all over the world. We report 3 cases (2 imported cases and 1 local case) with documented viral shedding (based on reverse transcription-polymerase chain reaction (RT-PCR) testing) of SARS-CoV-2 for 55, 59 and 63 days.

Establishing seasonal and alert influenza thresholds in Morocco.

Background: Several statistical methods of variable complexity have been developed to establish thresholds for influenza activity that may be used to inform public health guidance. We compared the results of two methods and explored how they worked to characterize the 2018 influenza season performance-2018 season.

Methods: Historical data from the 2005/2006 to 2016/2018 influenza season performance seasons were provided by a network of 412 primary health centers in charge of influenza like illness (ILI) sentinel surveillance.

Dissecting the Interaction Deficiency of a Cartilaginous Fish Digestive Lipase with Pancreatic Colipase: Biochemical and Structural Insights.

A full-length cDNA encoding digestive lipase (SmDL) was cloned from the pancreas of the smooth-hound (). The obtained cDNA was 1350 bp long encoding 451 amino acids. The deduced amino acid sequence has high similarity with known pancreatic lipases.

Fourth meeting of the Eastern Mediterranean Acute Respiratory Infection Surveillance (EMARIS) network and first scientific conference on acute respiratory infections in the Eastern Mediterranean Region, 11-14 December, 2017, Amman, Jordan.

Influenza causes significant morbidity and mortality worldwide. Owing to its ability to rapidly evolve and spread, the influenza virus is of global public health importance. Information on the burden, seasonality and risk factors of influenza in countries of the World Health Organization Eastern Mediterranean Region is emerging because of collaborative efforts between countries, WHO and its partners over the past 10 years.

Interplay between spin-crossover and luminescence in a multifunctional single crystal iron(ii) complex: towards a new generation of molecular sensors.

We present a new example of a mononuclear iron(ii) complex exhibiting a correlated spin-crossover (SCO) transition and strong fluorescence, whose coordination sphere is saturated, for the first time, by six phosphorescent ligands. The interplay between SCO and light emission properties in the thermal region of the spin transition was investigated by means of magnetic, fluorescence, optical absorption and optical microscopy measurements on a single crystal. Overall, the results show an excellent correlation between fluorescence and magnetic data of the present gradual transition, indicating an extreme sensitivity of the optical activity of the ligand to the spin state of the active iron(ii) ions.

Fourth meeting of the Eastern Mediterranean Acute Respiratory Infection Surveillance (EMARIS) network and first scientific conference on acute respiratory infections in the Eastern Mediterranean Region, 11-14 December, 2017, Amman, Jordan.

Influenza causes significant morbidity and mortality worldwide. Owing to its ability to rapidly evolve and spread, the influenza virus is of global public health importance. Information on the burden, seasonality and risk factors of influenza in countries of the World Health Organization Eastern Mediterranean Region is emerging because of collaborative efforts between countries, WHO and its partners over the past 10years.

One-Dimensional Thiocyanato-Bridged Fe(II) Spin Crossover Cooperative Polymer With Unusual FeNS Coordination Sphere.

We present here a novel example of spin crossover phenomenon on a Fe(II) one-dimensional chain with unusual NS coordination sphere. The [{Fe(tpc-OMe)(NCS)(μ-NCS)} ] (1) compound was prepared using the tridentate tpc-OMe ligand (tpc-OMe = tris(2-pyridyl)methoxymethane), FeCl·4HO, and the KSCN salt. Crystallographic investigations revealed that the Fe(II) ions are connected by a single bridging NCS ligand (μ-κN:κS-SCN coordination mode) to afford a zigzag neutral chain running along the [010] direction, in which the thiocyanato bridging groups adopt a cis head-to-tail configuration.

A Novel SYNJ1 Mutation in a Tunisian Family with Juvenile Parkinson's Disease Associated with Epilepsy.

Mutations in SYNJ1 gene have been described in few families with juvenile atypical Parkinson disease (PD). This gene encodes for "Synaptojanin 1," an enzyme playing a major role in the phosphorylation and the recycling of synaptic vesicles. In this study, we report two siblings, from a consanguineous Tunisian family, presenting juvenile PD.

Interplay between a crystal's shape and spatiotemporal dynamics in a spin transition material.

We investigated by means of optical microscopy (OM) the spatiotemporal features of the thermo-induced spin transition of [Fe(2-pytrz)2{Pd(CN)4}]·3H2O (1) (2-pytrz = 4-(2-pyridyl)-1,2,4,4H-triazole) single crystals having two different shapes (triangle and rectangle). While magnetic and calorimetric measurements, performed on a polycrystalline material, showed the respective average heating and cooling transition temperatures of (Tdown1/2 ∼ 152 K, Tup1/2 ∼ 154 K) and (Tdown1/2 ∼ 160.0 K, Tup1/2 ∼ 163.

On the Magnetic Coupling and Spin Crossover Behavior in Complexes Containing the Head-to-Tail [Fe(μ-SCN)] Bridging Unit: A Magnetostructural Experimental and Theoretical Study.

A new dinuclear complex [{Fe(tpc-OBn)(NCS)(μ-NCS)}] (1) based on the tripodal tpc-OBn ligand (tpc-OBn = tris(2-pyridyl)benzyloxymethane), containing bridging μ-κN:κS-SCN and terminal κN-SCN thiocyanate ligands, has been prepared and characterized by single crystal X-ray diffraction, magnetic studies, and DFT theoretical calculations. This complex represents the first example of dinuclear Fe complex with double μ-κN:κS-SCN bridges in a head-to-tail configuration that exhibits ferromagnetic coupling between metal ions (J = +1.08 cm).

Synergistic effect of polysaccharides, betalain pigment and phenolic compounds of red prickly pear (Opuntia stricta) in the stabilization of salami.

The aim of this work is to try to substitute some synthetic additives by a natural extract from red prickly pear (Opuntia stricta) which known by its richness on bioactive polysaccharides mainly consisting of galactose, rhamnose and galacturonic acid. This natural fruit has a high content of carbohydrates above 18.81% FM.

Synthetic ability of dinuclear mesocates containing 1,3-bis(diazinecarboxamide)benzene bridging ligands to form complexes of increased nuclearity. Crystal structures, magnetic properties and theoretical studies.

Triple stranded Ni-metallacyclic complexes Na[Ni(bpcb)]·0.5OH·18.5HO (1) and Na[Ni(bpzcb)]·16HO (2), and double stranded Cu-metallacyclic complexes [Cu(bpcb)(HO)]·8HO (3) and [Cu(bpzcb)(HO)]·4HO (4) have been assembled from the tailored bisbidentate bridging ligands, 1,3-bis(pyrimidine-2-carboxamide)benzene (Hbpcb) and 1,3-bis(pyrazine-2-carboxamide)benzene (Hbpzcb), and the corresponding nitrate salts of the metal ions.