The Combined Use of 5-ALA and Chlorin e6 Photosensitizers for Fluorescence-Guided Resection and Photodynamic Therapy under Neurophysiological Control for Recurrent Glioblastoma in the Functional Motor Area after Ineffective Use of 5-ALA: Preliminary Results.

The treatment of glial brain tumors is an unresolved problem in neurooncology, and all existing methods (tumor resection, chemotherapy, radiotherapy, radiosurgery, fluorescence diagnostics, photodynamic therapy, etc.) are directed toward increasing progression-free survival for patients. Fluorescence diagnostics and photodynamic therapy are promising methods for achieving gross total resection and additional treatment of residual parts of the tumor.

A Pilot Study of Fluorescence-Guided Resection of Pituitary Adenomas with Chlorin e6 Photosensitizer.

Fluorescence diagnostics is one of the promising methods for intraoperative detection of brain tumor boundaries and helps in maximizing the extent of resection. This paper presents the results of a pilot study on the first use of the chlorin e6 photosensitizer and a two-channel video system for fluorescence-guided resection of pituitary adenomas. The study's clinical part involved two patients diagnosed with hormonally inactive pituitary macroadenomas and one patient with a hormonally active one.

[Long-term postoperative outcomes in patients with drug-resistant epilepsy].

Unlabelled: Epilepsy surgery is effective in 30-82% of patients with drug-resistant epilepsy. However, risk factors of unfavorable outcomes after epilepsy surgery require further study.

Objective: To evaluate risk factors of favorable and unfavorable long-term postoperative outcomes in patients with drug-resistant epilepsy.

[Long-term EEG monitoring in patients with acute traumatic brain injury].

Objective: To investigate the informativeness of long-term scalp EEG monitoring in patients with acute traumatic brain injury (TBI).

Material And Methods: The informativity of long-term EEG monitoring (LTM) was performed in 60 patients with acute severe TBI. Odd ratios (OR) of unfavorable outcome and non-convulsive status epilepticus (NCSE) among clinical, neurophysiological and radiological features were calculated.

Laser-induced fluorescent visualization and photodynamic therapy in surgical treatment of glial brain tumors.

High-grade gliomas have a diffuse and infiltrative nature of the growth of tumor cells, due to which the achievement of radical resection is difficult. Surgical resection completeness of brain tumors is an important factor in prolonging the life of patients. An accurate definition of tumor boundaries and residual fluorescent regions is impossible due to imperfections of the equipment used for fluorescent imaging.

[Electroencephalography in acute stroke].

Objective: To determine the incidence of non-convulsive status epilepticus, epileptiform activity, rhythmic and periodic patterns in patients with acute stroke.

Material And Method: An analysis of electroencephalography (EEG) in 86 stroke patients in the neurointensive care unit of the tertiary medical center was performed. Criteria for starting EEG recording were epileptic seizures or clinical suspicion of uncontrolled epileptic status.

[Prognosis for surgical treatment of pharmacoresistant epilepsy: the role of mental and cognitive disorders].

This review focuses on the role of mental and cognitive disorders in the prognosis for surgical treatment of pharmacoresistant epilepsy. The authors analyze historical aspects of the surgical treatment of epilepsy and present current data on the prognosis of operative intervention with respect to seizure control, cognitive functioning, and psychiatric disorders. The psychiatrist's role in the structure of preoperative and postoperative management of patients is considered.

[Posttraumatic seizures: a prospective cohort study].

Aim: To evaluate the incidence and risk factors for posttraumatic seizures (PTS).

Material And Methods: The authors conducted a prospective study of 237 patients with TBI of varying severity. The patients were hospitalized and examined in Moscow neurosurgery departments.

[Surgical treatment patients with drug-resistant unilateral MRI-positive temporal forms of epilepsy].

Aim: To evaluate the results of surgical treatment of patients with unilateral MRI-positive temporal forms of drug-resistant epilepsy.

Material And Methods: A prospective analysis of 50 patients with unilateral MRI-positive temporal forms of drug-resistant epilepsy, who had undergone resective surgery in the Scientific Research Institute of Emergency Medicine of N.V.

[Subcortical laminar heterotopia 'double cortex syndrome'].

This article presents a clinical case of a 29-year-old patient with 'Double cortex syndrome' with epilepsy, intellectual and mental disorders. Subcortical band heterotopia is a rare disorder of neuronal migration. Such patients typically present with epilepsy and variable degrees of mental retardation and behavioral and intellectual disturbances.

[Outcomes of surgical treatment of patients with pharmacoresistant epilepsy].

Aim: To evaluate the results of surgical treatment of patients with pharmacoresistant epilepsy.

Material And Methods: Examination and surgical treatment of 61 patients with pharmacoresistant forms of symptomatic epilepsy were performed from 01.01.

[COMPLICATION AFTER UNRECOGNIZED ECTOPIC PREGNANCY--A CASE REPORT].

The authors present a clinical case of performing an abortion at patient with unrecognized ectopic pregnancy and subsequent complication- perforation of the uterus and the colon and life-threatening haemoperitoneum.

[Successful full-term pregnancy in the Herlyn-Werner-Wunderlich syndrome: a case report and review of literature].

Herlyn-Werner-Wunderlich Syndrome results in a doubling of the internal genitalia accompanied by unilateral gynatresia (with hemi-hematokolpos, hemi-hematometra and/or hemi-hematosalpings) and ipsilateral renal agenesis. The authors considered the case of a successful full-term pregnancy in one uterus after pregnancy failure in the other imposed surgical removal of the same.

[Ovarian vein thrombophlebitis during pregnancy--with a contribution of one clinical case].

Ovarian vein thrombosis (OVT) is a rare, but serious condition that affects mostly postpartum women but may also be associated with pelvic inflammatory disease, malignancies and pelvic surgical procedures. Concerning ovarian vein thrombosis in earlier stages of pregnancy there are only very few case reports. The authors consider this rare but potentially deadly disease and describe the clinical case study.

[Amniotic embolism--damocles sword or lifebelt?].

The author deals with classical and contemporary concepts of amniotic embolism in terms of medical and legal aspects associated with this potentially lethal condition.

[Balloon-uterine tamponade in acute postpartum haemorrhage].

Each year about 500,000 mothers die worldwide as 24 to 60% of deaths due to postpartum haemorrhage. The author presents a balloon-tamponade of the uterus as an effective weapon in the fight against postnatal bleeding. Requests are publications on the subject in different journals cited in Medline, Cochrane library, Nature, Science, Lancet, GyneWeb and others.

[Placenta percreta with a contribution of 1 clinical case].

Placenta accreta and its variants increta and percreta is one of the biggest challenges in clinical obstetric practice. The frequency of this life-threatening abnormality in the placenta tends to increase, this trend is directly linked to increasing rates of Caesarean section. The author describes clinical case of unrecognized before birth Placenta percreta, risk factors for this condition and modern methods for timely diagnosis and behavior.

[Assessment of rate of infection with agents of bacterial infections in ticks captured on one of the Moscow park terrains].

Aim: To study the rate of infection of ticks captured one of the Moscow park terrains with bacteria (agents of tick borreliosis and anaplasmosis).

Materials And Methods: Rates of infection of dried ticks with agents of main tick-borne bacterial infections (tick borreliosis and anaplasmosis) were determined by nested PCR.

Results: In May-June 2006, 76 ticks (40 adult females, 36 adult, males) belonged to Ixodes ricinus species were captured by the method "on flag".

[Admission and predischarge levels of NT pre brain natriuretic peptide in patients hospitalized because of worsening heart failure. relation to risk of death in the next 6-12 months].

Unlabelled: Inhospital treatment of patients with heart failure (HF) can cause changes of N-terminal pro-brain natriuretic peptide (NT proBNP) levels. It has not been established yet which NT proBNP value (before or at height of treatment activation) is closer related to prognosis of unfavorable outcome after discharge.

Aim: To compare relation to risk of post discharge unfavorable outcome of patients with HF of NT proBNP levels measured close to hospital admission and discharge.

[Abdominal expression of the fetus in the 21st century].

Exercising pressure to the bottom of the uterus in different ways in order to accelerate the second period of giving birth is a widespread practice in the obstetrics departments of the country, which is generally not recorded in the history of the disease and in the rare cases when this is done it is indicated as "Kristeller method". Studies on the topic have been been published in various journals cited in Medline, Cochrane library, Nature, Science, Lancet, GyneWeb and others. Keywords used are: "Pressure, Fundal pressure, Expression abdominale, Obstetric Labor Complications, Kristeller maneuver second stage of labor".

[Registry of patients with advanced ovary carcinoma in the province of Stara Zagora].

A representative inquiry has been conducted including the most important parameters from the medical files of 61 out-patients with ovarian carcinoma in III or IV stage in the province of Stara Zagora for the period 1997, 1998 and 1999. The prevailing majority are urban citizens /72.13%/, mainly aged over 60 /62.

[Heart fatty acid binding protein in patients hospitalized because of worsening heart failure. Relation to prognosis of death].

Purpose: We tested the hypothesis that serum heart fatty-acid binding protein (FABP), an early marker of myocardial necrosis, is related to prognosis of patients hospitalized because of worsening heart failure (HF).

Methods: Sixty nine patients (64% men, age 66.6 +/- 11.