Publications by authors named "Trieu M Van"
Article Synopsis
- The study investigates the differences in immune response to immune checkpoint blockade (ICB) between cutaneous melanoma (CM) and uveal melanoma (UM) patients, focusing on metastases in the liver.
- Researchers analyzed liver samples from both CM and UM patients, using various genomic, transcriptional, and protein-level techniques.
- Findings revealed that while CM and UM share a melanoma lineage, they significantly differ in mutation profiles and immune markers, with CM showing higher PD-L1 expression and UM demonstrating a higher ratio of exhausted CD8 T cells, suggesting distinct mechanisms behind their responses to ICB.
Approximately, 50% of patients with uveal melanoma develop distant metastasis for which no standard therapy is established. In contrast to cutaneous melanoma, the anti-CTLA-4 antibody ipilimumab showed no clinical activity in uveal melanoma. Liver directed therapies improve local control, but fail to show overall survival (OS) benefit.
View Article and Find Full Text PDFCharacterization of spatial protein expression for multiple targets from a single tissue is difficult to perform, especially due to the limitations of multiplex immunohistochemistry and tissue heterogeneity. Therefore, a new technology is required that permits detailed and simultaneous expression profiling of proteins within a defined region of interest (ROI). To address this unmet need, NanoString Technologies developed a new technology, GeoMx digital spatial profiling (DSP), which currently enables simultaneous and guided detection of up to 40 antibodies (probes) from a single formalin-fixed paraffin-embedded (FFPE) tissue.
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