Publications by authors named "Tricia Lindstrom"
Article Synopsis
- This research identifies 290 genetic factors linked to ovarian ageing by analyzing the age at natural menopause in 200,000 European women, highlighting how genetics can influence reproductive lifespan.* -
- The study reveals that these genetic variants are connected to DNA damage response processes that impact ovarian reserve and depletion rates, suggesting potential therapeutic targets.* -
- Manipulating these pathways in experimental models showed promise in boosting fertility and extending reproductive longevity, while also indicating benefits and risks for women's overall health, such as improved bone health but increased cancer risk.*
Article Synopsis
- A correction has been issued for the paper referenced by the DOI 10.1038/s41467-021-23162-4.
- The correction addresses specific errors or inaccuracies found in the original research.
- Readers are encouraged to review the correction to understand the updated findings and implications.
Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies.
View Article and Find Full Text PDFBackground: Population-based estimates of the risk of breast cancer associated with germline pathogenic variants in cancer-predisposition genes are critically needed for risk assessment and management in women with inherited pathogenic variants.
Methods: In a population-based case-control study, we performed sequencing using a custom multigene amplicon-based panel to identify germline pathogenic variants in 28 cancer-predisposition genes among 32,247 women with breast cancer (case patients) and 32,544 unaffected women (controls) from population-based studies in the Cancer Risk Estimates Related to Susceptibility (CARRIERS) consortium. Associations between pathogenic variants in each gene and the risk of breast cancer were assessed.
Purpose: To compare the clinical characteristics and overall survival (OS) of germline mutation carriers in homologous recombination repair (HRR) genes and noncarriers with pancreatic ductal adenocarcinoma (PDAC).
Experimental Design: Germline DNA from 3,078 patients with PDAC enrolled in a prospective registry at Mayo Clinic between 2000 and 2017 was analyzed for mutations in 37 cancer predisposition genes. Characteristics and OS of patients with mutations in eight genes and involved in HRR were compared with patients testing negative for mutations in all 37 genes.
Purpose: To determine the sensitivity and specificity of genetic testing criteria for the detection of germline pathogenic variants in women with breast cancer.
Materials And Methods: Women with breast cancer enrolled in a breast cancer registry at a tertiary cancer center between 2000 and 2016 were evaluated for germline pathogenic variants in 9 breast cancer predisposition genes (, and ). The performance of the National Comprehensive Cancer Network (NCCN) hereditary cancer testing criteria was evaluated relative to testing of all women as recommended by the American Society of Breast Surgeons.