[Unformed conglomerate debilitating jejunal fistulas and their two-stage surgical treatment via posterolateral laparotomy].

Objective: To create a method of two-stage repair of high unformed conglomerate delimited debilitating jejunal fistulas via posterolateral laparotomy with low risk of surgical complications.

Material And Methods: Methodology and treatment outcomes were analyzed in 37 patients with unformed conglomerate high debilitating delimited jejunal fistulas. Of these, 22 patients underwent one-stage treatment through 2 converging incisions and/or two-stage treatment through anterolateral access.

[Surgical treatment of diabetic neuroosteoarthropathy (DNOAP) and its long-term results].

Aim: To develop pathogenetically justified surgical treatment of diabetic neuroosteoarthropathy (DNOAP).

Material And Methods: 52 patients were operated and long-term results were studied in 36 of them. 2 groups were assessed depending on completeness of surgical treatment including changed synovial structures removal.

[Laparotomy closure in advanced peritonitis].

Aim: to improve the results of advanced peritonitis management.

Material And Methods: 743 patients with advanced peritonitis were studied. Patients were divided into 2 groups depending on treatment strategy.

Lymphoprotective effect of perftoran.

Experiments on rats showed that the lymphoprotective effect of Perftoran manifests in stimulation of contractile activity of myocytes in the wall and valve cusps of lymphatic microvessels, which in turn activates the pump and capacitive functions of the lymphatic system and improves central lymph outflow. These changes contribute to an increase in the resorption and transport of cell and tissue metabolites from the interstitial space.

Content of trace elements in the lymph and blood during pyrogenal-induced fever and complete freund's adjuvant-induced low-grade fever.

Experiments on rats showed that complete Freund's adjuvant-induced low-grade fever and pyrogenal-induced fever are accompanied by an increase in the content of Mn, Cu, Zn, and Se in the thoracic duct lymph. Our results indicate that the lymphatic system supplies trace elements to the circulation, which compensates for a deficiency in trace elements and maintains their systemic circulation. The decrease in the content of some trace elements in the blood during fever is probably associated with their excessive consumption (e.

Antioxidant protection and lipid peroxidation in the lymph and blood during complete Freund's adjuvant-induced low-grade fever and pyrogenal-induced fever.

Experiments on rats showed that complete Freund's adjuvant-induced low-grade fever and pyrogenal-induced fever of different duration are accompanied by an increase in the content of lipid peroxidation products and components of the antioxidant system not only in blood plasma, but also in the central lymph. These changes reflect activation of drainage, evacuation, and transport function of the lymphatic system. We conclude that the lymphatic system plays an important role in the maintenance of the prooxidant-antioxidant balance under these pathological conditions.

Change in lymph flow during low-grade fever and febrile fever under experimental conditions.

Experiments on rats showed that low-grade fever is accompanied by a decrease in the central lymph flow rate, which results from inactivation of lymphangion components in lymphatic microvessels of the small intestine mesentery. Lymph flow rate was shown to increase during pyrogenal-induced fever, which did not depend on the duration of the disease.

[Debatable questions in diabetic foot syndrome classification].

The experience of treatment of 705 patients with the diabetic foot syndrome (DFS) determined the necessity of reviewing the existing classifications of the disease. Main features of clinics and pathology define three basic forms of the DFS: neuropathic, neuroischemic and ischemic. The new ischemia classification is brought forward.

[Prevention of extremities amputation in patients with diabetic foot complications].

In order to decrease the number of amputations for "diabetic foot", these patients should undergo elective or delayed operations. It is obligatory before the operation to correct carbohydrate metabolism and hemodynamics. Sodium succinate in combination with conventional angioprotective treatment is used for this purpose.