The potential of in preventing complications of diabetes mellitus as an antidiabetic and antihyperlipidemic agent.

Background: Hyperglycemia in diabetes mellitus (DM) can lead to dyslipidemia, which is a risk factor for macrovascular complications such as heart disease and stroke. Aside from administering antidiabetic medications, DM treatment can also be achieved through the use of natural components, such as , commonly known as the ant nest plant (ANP).

Aim: This study aimed to investigate the impact of administering the ANP on the lipid profile of Wistar rats.

The anti-obesity properties of leaf extract in rats fed a high-fat diet through inhibition of adipogenesis.

Objective: Various disease complications are a risk of overweight or obesity, so losing weight can reduce the risk of diseases caused by obesity. Binahong leaf ethanol extract () is a weight-loss herbal preparation.

Aim: This study aims to analyze whether extract is effective in losing weight by affecting the mechanism of adipogenesis in an animal obesity model.

The potential of Andaliman ( DC) fruit as an ethanol extract for neuroprotection in aged model rat.

Objective: Dementia is a common aging-related neurodegenerative disease in the elderly worldwide. Alterations in neurogenesis and angiogenesis factors have been linked to cognitive impairment in neurological disorders. However, synthetic drugs to improve memory disorders have uncomfortable side effects.

Effect of (Scheff.) Boerl Leaf Ethanol Extract on Serum IL-6 and TNF-α Levels in Diabetic Rats.

Background: Hyperglycemia conditions in diabetes mellitus (DM) can turn on pro-inflammatory cytokines like IL-6 and TNF-α. These cytokines play a role in insulin resistance and the development of DM complications. People in Indonesia have used to treat diabetes, but the leaf of this plant has not been studied to see if it can reduce inflammation.

Effect of Using Ethanol Extract of Artocarpus Heterophyllus Leaves and Olea Europea Fruit Oil Combination on Facial Skin.

Background: leaves and (OE) fruit oil are natural sources that have been traditionally used for health and skin care purpose.

Objective: To assess the potential synergistic effect of combining ethanol extract of leaves (AHLE) and OE fruit oil in the formulation of clay masks, specifically in terms of their effect on facial skin.

Methods: AHLE was obtained by the maceration method, while OE was purchased commercially.

Study of the Molecular Dynamics Stability in the Inhibitory Interaction of Tenofovir Disoproxil Fumarate against CTLA-4 in Chronic Hepatitis B Patients.

Background: Tenofovir disoproxil fumarate (TDF) is a first-line nucleotide analog (NA) drug for hepatitis B therapy. Long-term NA therapy increases peripheral T cell levels to enhance antiviral response, while CTLA-4 inhibits the activation.

Objective: This study analyzed the interaction between TDF and CTLA-4 through molecular docking.

Association Between Serum Cytotoxic T Lymphocyte Antigen (CTLA)-4 Level and Disease Progression in Patients With Chronic Hepatitis B.

Backgroud: Immune impairment, marked by increased expression of cytotoxic T lymphocyte antigen (CTLA)-4, promotes the disease progression of chronic hepatitis B.

Objective: This study aimed to determine the association between serum CTLA-4 level and disease progression in patients with chronic hepatitis B.

Methods: A cross-sectional study was conducted at Haji Adam Malik General Hospital Medan, Indonesia between October 2021 to September 2022.

Analysis of Antidiabetic Activity of Squalene via In Silico and In Vivo Assay.

Squalene has been tested widely in pharmacological activity including anticancer, antiinflammatory, antioxidant, and antidiabetic properties. This study aims to examine antidiabetic activity of squalene in silico and in vivo models. In the in silico model, the PASS server was used to evaluate squalene antidiabetic properties.

Bioactivity-Guided Fractionation and Identification of Antidiabetic Compound of (Wight.)'s Leaf Extract in Streptozotocin-Induced Diabetic Rat Model.

(1) Background: An earlier study on the hypoglycemic activity of S. polyanthum (Wight.) leaf methanol extract identified squalene as the major chemical compound.

Potential benefit of olive leaf extract in cervical spondylotic myelopathy model.

Introduction: Cervical spondylosis is the most common cause of myelopathy in the cervical due to chronic compression of the spinal cord in patients aged 55 years or older. Recent studies suggest that olive extracts suppress inflammation and reduce stress oxidative injury. The purpose of this study was to determine the potential neuroprotective effects of olive leaf extract (OLE) in an experimental cervical spondylotic myelopathy model.

The Effectivity of Ethanolic Extract from Papaya Leaves ( L.) as an Alternative Larvacide to spp.

Background: Dengue haemorrhagic fever (DHF) is a disease found in most tropical and subtropical regions of the world, including Indonesia. One of the problems of vector control programs is insecticides resistance to Aedes spp.

Aim: The objective of this study is to determine the effectiveness of an alternative larvacide using papaya leaves ( L).

Nypa fruticans Wurmb. Vinegar's Aqueous Extract Stimulates Insulin Secretion and Exerts Hepatoprotective Effect on STZ-Induced Diabetic Rats.

Background: An aqueous extract (AE) of vinegar made from Wurmb. can improve postprandial glucose levels in normoglycaemic rats. The aim of this study was to evaluate its antihyperglycaemic activity further using in vivo and in vitro approaches.

Antihyperglycemic Effect of Methanol Extract of Syzygium polyanthum (Wight.) Leaf in Streptozotocin-Induced Diabetic Rats.

Syzygium polyanthum (S. polyanthum), a plant belonging to Myrtaceae, is widely used in Indonesian and Malaysian cuisines. Diabetic patients in Indonesia also commonly use it as a traditional medicine.

Antidiabetic and antioxidant activities of Nypa fruticans Wurmb. vinegar sample from Malaysia.

Objectives: To study the antidiabetic and antioxidant activities of nipa palm vinegar (NPV) used in traditional Malay medicine for treating diabetes.

Methods: NPV was extracted using liquid-liquid extraction method and the obtained samples were subjected to antidiabetic studies using normal and streptozotocin-induced diabetic rat models whereas antidoxidant activities were investigated via in vitro antioxidant tests namely 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azinobis-3-ethylbenzothiozoline-6-sulfonic acid free radicals scavenging activities and the reducing power assay.

Results: Single administration of NPV and its extracts were not effective in both normal and diabetic rats.

Aqueous Extract of Nypa fruticans Wurmb. Vinegar Alleviates Postprandial Hyperglycemia in Normoglycemic Rats.

Nypa fruticans Wurmb. vinegar, commonly known as nipa palm vinegar (NPV) has been used as a folklore medicine among the Malay community to treat diabetes. Early work has shown that aqueous extract (AE) of NPV exerts a potent antihyperglycemic effect.