Activation of (K7) K channels in enteric neurons inhibits epithelial Cl secretion in mouse distal colon.

Voltage-gated Kv7 ( family) K channels are expressed in many neuronal populations and play an important role in regulating membrane potential by generating a hyperpolarizing K current and decreasing cell excitability. However, the role of K7 channels in the neural regulation of intestinal epithelial Cl secretion is not known. Cl secretion in mouse distal colon was measured as a function of short-circuit current (I), and pharmacological approaches were used to test the hypothesis that activation of K7 channels in enteric neurons would inhibit epithelial Cl secretion.

Calcium-Activated Cl Channel: Insights on the Molecular Identity in Epithelial Tissues.

Calcium-activated chloride secretion in epithelial tissues has been described for many years. However, the molecular identity of the channel responsible for the Ca-activated Cl secretion in epithelial tissues has remained a mystery. More recently, TMEM16A has been identified as a new putative Ca-activated Cl channel (CaCC).

Dextran sulfate sodium-induced chronic colitis attenuates Ca-activated Cl secretion in murine colon by downregulating TMEM16A.

Attenuated Ca-activated Cl secretion has previously been observed in the model of dextran sulfate sodium (DSS)-induced colitis. Prior studies have implicated dysfunctional muscarinic signaling from basolateral membranes as the potential perpetrator leading to decreased Ca-activated Cl secretion. However, in our chronic model of DSS-colitis, cholinergic receptor muscarinic 3 ( Chrm3) transcript (1.

Critical contribution of KV1 channels to the regulation of coronary blood flow.

Ion channels in smooth muscle control coronary vascular tone, but the identity of the potassium channels involved requires further investigation. The purpose of this study was to evaluate the functional role of KV1 channels on porcine coronary blood flow using the selective antagonist correolide. KV1 channel gene transcripts were found in porcine coronary arteries, with KCNA5 (encoding KV1.

Diphenyl phosphine oxide-1-sensitive K(+) channels contribute to the vascular tone and reactivity of resistance arteries from brain and skeletal muscle.

Objective: Many types of vascular smooth muscle cells exhibit prominent KDR currents. These KDR currents may be mediated, at least in part, by KV1.5 channels, which are sensitive to inhibition by DPO-1.

Bisphenol A activates BK channels through effects on α and β1 subunits.

We demonstrated previously that BK (K(Ca)1.1) channel activity (NP(o)) increases in response to bisphenol A (BPA). Moreover, BK channels containing regulatory β1 subunits were more sensitive to the stimulatory effect of BPA.