Publications by authors named "Trey J Pichon"
DNA Aptamer-Polymer Conjugates for Selective Targeting of Integrin α4β1 T-Lineage Cancers.
ACS Appl Mater Interfaces
January 2025
Selective therapeutic targeting of T-cell malignancies is difficult due to the shared lineage between healthy and malignant T cells. Current front-line chemotherapy for these cancers is largely nonspecific, resulting in frequent cases of relapsed/refractory disease. The development of targeting approaches for effectively treating T-cell leukemia and lymphoma thus remains a critical goal for the oncology field.
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- Traumatic injury is a major global cause of suffering and death, highlighting the need for effective prehospital therapies that balance organ perfusion and blood loss.
- Current options for damage control resuscitation (DCR) are limited, prompting research into synthetic polymers as injectable therapies that are portable and stable in tough conditions.
- This study designs and tests a specific polymer, which shows promise by not interfering with blood coagulation and effectively resuscitating rats from severe blood loss, suggesting its potential use in trauma medicine.
Article Synopsis
- Trauma and severe bleeding can lead to death within 3 to 6 hours, making urgent treatment crucial, especially in low- to middle-income countries where transport times can be lengthy.
- First-generation intravenous hemostats use advanced drug delivery methods, but have struggled to pass preclinical and clinical trials successfully.
- The text explores hemorrhagic shock physiology, introduces a new low volume resuscitant called PEG-20k, and emphasizes the need for thoughtful design in developing effective resuscitation strategies.
Article Synopsis
- Critical illness triggers rapid consumption of fibrinogen and leads to coagulopathy, which heightens bleeding risk and mortality.
- In a study using rats, researchers observed that fibrinogen becomes oxidized and degraded within hours due to inflammation induced by lipopolysaccharides (LPS).
- The activation of immune cells such as neutrophils and monocytes significantly contributes to this process, suggesting that targeting oxidative stress could be more effective in preventing coagulopathy than traditional treatments like tranexamic acid.
Article Synopsis
- There is a need for better prehospital hemostatic agents for treating uncontrolled bleeding, especially for injuries where compression isn't effective.
- The research improved the water-solubility and production efficiency of a hemostatic agent called PolySTAT by changing its polymer backbone, using a new monomer, GmMA, which enhances clot effectiveness without losing performance.
- The study also introduced a new method for synthesizing PolySTAT using direct polymerization of peptide monomers, which boosts production yield while retaining effectiveness, making it a promising option for mass production.
Article Synopsis
- Cell therapy for spinal cord injuries uses synthetic hydrogels to help transplanted cells survive and integrate into the damaged central nervous system, mimicking healthy tissue features.
- Researchers have created peptide-functionalized polymers that can form hydrogels that not only resemble the properties of natural extracellular matrix but also include peptides to inhibit scar formation.
- Although the survival rate of embedded cells is low, cells grown on these hydrogels show good viability, making them promising candidates for CNS regeneration applications.