Publications by authors named "Trevor Torigoe"
Article Synopsis
- Nonagenarians and centenarians illustrate successful aging and effective biological regulation, highlighting a complex area of study focused on longevity.
- The research explores microRNAs, which regulate gene expression, across different age groups, particularly examining those in Okinawa based on genetic variations.
- The study identifies five microRNAs that are upregulated in nonagenarians with a longevity-associated genotype, suggesting they may play a role in extending lifespan and health span, indicating the need for further research in this area.
Introduction: Dynamic catheter-directed cerebral digital subtraction angiography (dcDSA) is the gold standard for diagnosing dynamic vascular occlusion syndromes such as bowhunter syndrome (BHS). Nonetheless, concerns about its safety exist and no standardized protocols have been published to date.
Methods: We describe our methodology and insights regarding the use of dcDSA in patients with BHS.
Article Synopsis
- - The study investigates how the FOXO3 longevity variant rs2802292 relates to factors like telomere length, telomerase activity, FOXO3 expression, and inflammation in older adults.
- - Carriers of the FOXO3 G-allele showed protection against telomere shortening and higher telomerase activity, suggesting a link between this genetic variant and longevity.
- - The findings indicate that FOXO3's influence on aging may vary between men and women, with older females showing reduced inflammatory cytokines and older males showing increased anti-inflammatory cytokines.
Purpose: Extended reality (XR) technology enhances learning in medical education. The purpose of this study was to develop and apply a case-based approach for teaching radiological anatomy utilizing XR technology for improved student exploration and engagement.
Methods: The workflow consisted of MRI scanning cadavers followed by radiological, pathological, and anatomical assessment, and finally case presentation based on XR visualizations and student interaction.
The rs2802292, rs2764264 and rs13217795 variants of FOXO3 have been associated with extreme longevity in multiple human populations, but the mechanisms underpinning this remain unclear. We aimed to characterise potential effects of longevity-associated variation on the expression and mRNA processing of the FOXO3 gene. We performed a comprehensive assessment of FOXO3 isoform usage across a wide variety of human tissues and carried out a bioinformatic analysis of the potential for longevity-associated variants to disrupt regulatory regions involved in isoform choice.
View Article and Find Full Text PDFContext: Traditional nonweight-bearing (NWB) hip-strength assessments may not directly translate to functional strength during weight-bearing (WB) activity. How NWB assessments of hip muscle strength compare with WB assessments in various positions is currently unknown.
Objective: To determine the magnitude of the differences and correlations between NWB hip strength and WB functional strength during the squatting and lunge (LNG) positions in female athletes.
FOXO3 is one of the most prominent genes demonstrating a consistently reproducible genetic association with human longevity. The mechanisms by which these individual gene variants confer greater organismal lifespan are not well understood. We assessed the effect of longevity-associated FOXO3 alleles on age-related leukocyte telomere dynamics in a cross-sectional study comprised of samples from 121 healthy Okinawan-Japanese donors aged 21-95 years.
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